Date published: 2026-4-1

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SUSP4 Activators

The chemical class known as SUSP4 Activators encompasses various compounds that influence cellular processes and pathways which can lead to the activation of the SUMO-specific protease 4 (SUSP4). These activators operate through diverse mechanisms to affect the SUMOylation and deSUMOylation balance within cells. By targeting different aspects of the cellular machinery, these molecules can increase the activity of SUSP4. Some activators can exert their effects by inhibiting enzymes that are responsible for the addition of SUMO (Small Ubiquitin-like Modifier) groups to proteins, while others can modulate the proteasome system, which is crucial for protein degradation. Additionally, certain activators can alter lysosomal function, thereby impacting the turnover of proteins, including those that are SUMOylated.

Furthermore, activators within this class can also modulate various signaling pathways, such as those controlled by GSK-3β, PI3K/Akt/mTOR, which have downstream consequences on nuclear transport and protein synthesis. These effects, in turn, can lead to the activation of SUSP4. Some compounds within this class target histone acetyltransferases or sirtuins, thereby influencing transcriptional regulation that can lead to the activation of SUSP4. Collectively, the actions of these chemicals can lead to an increased presence of deSUMOylated proteins in the cell, which is indicative of heightened SUSP4 activity. The range of mechanisms these activators employ underscores the complexity of the cellular environment and the intricate interplay of pathways that converge to regulate protein function and activity.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Anacardic Acid

16611-84-0sc-202463
sc-202463A
5 mg
25 mg
$102.00
$204.00
13
(1)

Anacardic acid inhibits histone acetyltransferase, which could possibly activate SUSP4 by affecting transcription and SUMOylation-related transcriptional regulation.

(−)Epicatechin

490-46-0sc-205672
sc-205672A
1 mg
5 mg
$51.00
$138.00
(1)

Ginkgolic acid is known to inhibit SUMO-activating enzyme E1 and could possibly activate SUSP4 by affecting the overall SUMOylation process.

Tenovin-6

1011557-82-6sc-224296
sc-224296A
1 mg
5 mg
$272.00
$1214.00
9
(1)

Tenovin-6 acts as a SIRT1 and SIRT2 inhibitor, which could possibly activate SUSP4 by impacting deacetylation processes.

Tunicamycin

11089-65-9sc-3506A
sc-3506
5 mg
10 mg
$172.00
$305.00
66
(3)

Tunicamycin inhibits N-linked glycosylation, which could possibly activate SUSP4 by having a broad impact on cellular processes including SUMOylation.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

MG132 inhibits the proteasome, which could possibly activate SUSP4 by increasing the levels of SUMOylated proteins.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Lithium chloride affects GSK-3β signaling and could possibly activate SUSP4 by having downstream effects on nuclear transport and SUMOylation processes.

PI-103

371935-74-9sc-203193
sc-203193A
1 mg
5 mg
$33.00
$131.00
3
(1)

PI-103 is a PI3K/Akt/mTOR pathway inhibitor, which could possibly activate SUSP4 by altering cellular processes including SUMOylation.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is a PI3K inhibitor that could possibly activate SUSP4 by altering cellular processes, thereby potentially influencing the SUMOylation landscape.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin inhibits the mTOR pathway, which could possibly activate SUSP4 by having a broad range of effects on cell growth and protein synthesis.