stefin A1 Inhibitors
Stefin A1 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of Stefin A1, a cystatin family member responsible for regulating cysteine protease activity. Cysteine proteases, including cathepsins, are enzymes involved in various intracellular processes such as protein degradation, apoptosis, immune responses, and extracellular matrix remodeling. Stefin A1 plays a crucial role as an endogenous inhibitor of these proteases, controlling their activity to prevent excessive or unregulated proteolysis, which could otherwise lead to cellular damage or dysfunction. By binding to cysteine proteases, Stefin A1 maintains protease homeostasis, ensuring that protein degradation occurs in a controlled manner. Inhibitors of Stefin A1 work by blocking its ability to interact with and inhibit cysteine proteases, thereby allowing unregulated proteolytic activity.
The mechanism of action of Stefin A1 inhibitors typically involves binding to the active or interaction sites of the Stefin A1 protein, preventing it from associating with cysteine proteases. Some inhibitors may compete directly with proteases for binding or induce conformational changes in Stefin A1, reducing its ability to form stable complexes with target proteases. By inhibiting Stefin A1, these compounds disrupt the balance of protease activity, leading to changes in the degradation of proteins and potential alterations in cellular processes dependent on protease regulation. This can affect pathways involved in cell turnover, immune regulation, and tissue remodeling. Research into Stefin A1 inhibitors helps provide a deeper understanding of the role of protease inhibitors in cellular biology, shedding light on how cystatin family proteins like Stefin A1 regulate essential processes such as protein homeostasis and cell survival.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane inhibits Stefin A1 expression by modulating the activity of transcription factors involved in its regulation or by inducing epigenetic changes at its gene locus, leading to reduced transcriptional activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin may inhibit Stefin A1 expression by interfering with its mRNA stability, resulting in decreased levels of the protein within the cell. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol exhibits inhibitory effects on Stefin A1 expression by modulating key molecular pathways involved in its regulation, such as inhibition of certain transcription factors or induction of apoptosis. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein can downregulate Stefin A1 expression by modulating the activity of various signaling pathways involved in its transcriptional regulation, thereby reducing its overall abundance in the cell. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin inhibits the expression of Stefin A1 by downregulating its transcriptional activity through various signaling pathways or by interfering with its stability through post-translational modifications. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG suppresses Stefin A1 expression by interfering with its transcriptional machinery or through direct inhibition of protein-protein interactions essential for its function. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine inhibits Stefin A1 expression potentially by modulating the activity of transcription factors involved in its regulation or by disrupting its interaction with other cellular components necessary for its function. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin inhibits Stefin A1 expression by interfering with its transcriptional activity or by promoting its degradation through the ubiquitin-proteasome system. | ||||||
Gallic acid | 149-91-7 | sc-205704 sc-205704A sc-205704B | 10 g 100 g 500 g | $56.00 $87.00 $245.00 | 14 | |
Gallic acid inhibits Stefin A1 expression by interfering with the function of key transcription factors or by modulating chromatin structure at its gene locus, resulting in reduced transcriptional activity. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Silibinin inhibits Stefin A1 expression potentially by interfering with its post-translational modification or by disrupting its interaction with other cellular components critical for its stability or function. | ||||||