SSTR5 Activators are chemical that can indirectly influence SSTR5, a G-protein coupled receptor (GPCR) pivotal to numerous cellular processes. Several identified compounds can modify pathways and processes related to GPCR signaling, thereby having an effect on SSTR5. For instance, Forskolin, a known enhancer of cAMP levels, and Isoproterenol, a β-adrenergic receptor agonist, can influence GPCR signaling, potentially impacting the activity of SSTR5. Other compounds like Salmeterol and PGE2, functioning as a long-acting β2-adrenergic agonist and a prostaglandin respectively, are also capable of modulating various signaling pathways, subsequently affecting SSTR5. Additionally, compounds like Iloprost, a prostacyclin analog, and Rolipram, a PDE4 inhibitor, by influencing GPCR signaling, may also exert an influence on SSTR5 activity.Compounds that affect cellular signaling and metabolism, such as Resveratrol, also hold the capability to affect SSTR5. Similarly, compounds like Rosiglitazone and Pioglitazone, functioning as PPARγ agonists, can modulate the transcription of target genes, possibly having repercussions on SSTR5. Additionally, Capsaicin, identified as a TRPV1 agonist, can modulate ion channel activity, offering another route through which SSTR5 can be indirectly influenced.