SREB3 Activators

SREB3, also designated GPR173, is embedded within the intricate network of G protein-coupled receptors (GPCRs). Chemicals that modulate GPCR-associated signaling pathways can, therefore, serve as potential activators for SREB3/GPR173. A quintessential example is Forskolin, which enhances adenylyl cyclase activity leading to elevated cAMP levels, thereby modulating GPCR signaling dynamics. Similarly, the use of agents like Pertussis toxin and Cholera toxin, both influencing G-protein signaling, exemplify the depth of GPCR pathway manipulation.

Molecules such as Phorbol 12-myristate 13-acetate (PMA) target kinases like PKC, demonstrating the interconnectedness of kinases and GPCRs. On the other hand, ligands of other GPCRs, like Lysophosphatidic acid or Sphingosine-1-phosphate, shed light on potential signaling crosstalk within the GPCR family, indicating indirect ways to influence SREB3/GPR173. Beta-adrenergic and muscarinic receptor agonists, including Isoproterenol and Carbachol, respectively, highlight the breadth of GPCR signaling and its pervasive influence. The central role of cellular energy in the form of ATP and signaling molecules like calcium, symbolized by compounds like Calcium chloride and Dibutyryl cAMP, further underscore the multiplicity of indirect strategies that can be employed to engage with and possibly activate SREB3/GPR173.