Date published: 2025-12-9

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SR-2C Inhibitors

SR-2C inhibitors, also known as serotonin receptor 2C inhibitors, belong to a specific chemical class of compounds that are primarily designed to modulate the activity of the serotonin 2C receptor subtype in the human brain. The serotonin 2C receptor, abbreviated as 5-HT2C receptor, is a member of the G-protein coupled receptor (GPCR) family and is involved in the regulation of various physiological processes, including mood, appetite, and sleep. SR-2C inhibitors are characterized by their ability to selectively bind to and influence the function of these receptors, either by blocking or stimulating their activity, thus altering the downstream signaling pathways. These inhibitors are typically small organic molecules with a structure that allows them to interact with the serotonin 2C receptor in a specific manner. The binding of SR-2C inhibitors to the receptor can lead to diverse pharmacological effects, depending on their mode of action. Some compounds act as antagonists, effectively preventing serotonin or other endogenous ligands from binding to the receptor, thereby reducing its activation. Others may function as agonists, mimicking the effects of serotonin and activating the receptor. The modulation of 5-HT2C receptor activity by these inhibitors can have profound effects on the brain's neurotransmitter systems, leading to alterations in mood, appetite, and other behaviors. Consequently, SR-2C inhibitors represent a class of compounds that are of interest to researchers studying the neurobiology of mood and appetite regulation

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Items 11 to 20 of 27 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ketanserin tartrate

83846-83-7sc-201131
sc-201131A
50 mg
250 mg
$219.00
$775.00
(0)

Ketanserin tartrate, an SR-2C compound, exhibits intriguing stereochemical properties that influence its spatial orientation and reactivity. The presence of multiple chiral centers contributes to its ability to engage in selective molecular interactions, particularly through π-π stacking and van der Waals forces. Its crystalline structure enhances stability, while the tartrate moiety introduces additional ionic interactions, affecting solvation dynamics and reactivity in polar environments.

Mirtazapine

85650-52-8sc-204088
sc-204088A
10 mg
50 mg
$112.00
$422.00
(1)

Mirtazapine, classified as an SR-2C compound, showcases unique electronic characteristics due to its heterocyclic structure, which facilitates diverse intermolecular interactions. The compound's ability to form hydrogen bonds and engage in dipole-dipole interactions enhances its solubility in various solvents. Additionally, its conformational flexibility allows for dynamic reorganization in response to environmental changes, influencing its reactivity and stability in complex chemical systems.

Nafamostat mesylate

82956-11-4sc-201307
sc-201307A
10 mg
50 mg
$80.00
$300.00
4
(1)

Nafamostat inhibits TMPRSS2, blocking the priming of SARS-CoV-2 spike protein and preventing viral entry into host cells.

Agomelatine

138112-76-2sc-207266
10 mg
$133.00
2
(1)

Agomelatine, an SR-2C compound, exhibits intriguing photophysical properties attributed to its unique aromatic system, which allows for effective π-π stacking interactions. This characteristic enhances its stability in solution and influences its reactivity with electrophiles. The compound's ability to undergo tautomerization can lead to distinct isomeric forms, impacting its kinetic behavior in various chemical environments. Its hydrophobic regions contribute to selective solvation dynamics, further modulating its interactions in complex mixtures.

SB 206553 hydrochloride

158942-04-2 (non HCl Salt)sc-361334
sc-361334A
10 mg
50 mg
$225.00
$825.00
2
(0)

SB 206553 hydrochloride, classified as an SR-2C, demonstrates notable electrostatic interactions due to its charged functional groups, which facilitate strong hydrogen bonding with polar solvents. This compound exhibits a propensity for conformational flexibility, allowing it to adopt various spatial arrangements that influence its reactivity. Additionally, its unique electronic structure promotes specific charge transfer mechanisms, enhancing its reactivity in nucleophilic substitution reactions. The compound's solubility characteristics are also affected by its hydrophilic and lipophilic balance, impacting its behavior in diverse chemical systems.

SB 221284

196965-14-7sc-224281
5 mg
$203.00
(0)

SB 221284, an SR-2C compound, showcases intriguing reactivity patterns attributed to its unique functional groups that engage in dipole-dipole interactions. This acid halide exhibits a distinct tendency for rapid acylation reactions, driven by its electrophilic carbonyl carbon, which enhances its reactivity towards nucleophiles. Its steric properties contribute to selective reactivity, while its solvation dynamics reveal a balance between polar and nonpolar environments, influencing its overall stability and interaction profiles in various chemical contexts.

Lopinavir

192725-17-0sc-207831
10 mg
$129.00
6
(1)

Lopinavir inhibits the viral protease, preventing the processing of viral polyproteins and the formation of infectious virions.

SB 242084 hydrochloride

1049747-87-6sc-351848
sc-351848A
1 mg
5 mg
$100.00
$225.00
(0)

SB 242084 hydrochloride, classified as an SR-2C compound, demonstrates notable reactivity due to its specific halogen substituents, which enhance its electrophilic character. This acid halide engages in unique hydrogen bonding interactions, facilitating selective nucleophilic attacks. Its kinetic behavior is characterized by rapid reaction rates, influenced by solvent polarity, while its conformational flexibility allows for diverse molecular interactions, impacting its stability and reactivity in various environments.

Ritonavir

155213-67-5sc-208310
10 mg
$122.00
7
(1)

Ritonavir enhances the stability and effectiveness of lopinavir by inhibiting the same viral protease in SARS-CoV-2.

SB 228357

181629-93-6sc-361337
sc-361337A
10 mg
50 mg
$189.00
$781.00
(0)

SB 228357, classified as an SR-2C, showcases remarkable reactivity due to its distinctive electronic configuration and functional group arrangement. This compound engages in rapid acylation reactions, facilitated by its electrophilic nature, which allows for efficient nucleophilic attack. Its unique steric hindrance influences reaction kinetics, promoting specific pathways while minimizing side reactions. Furthermore, the compound's polarity and intermolecular interactions enhance its solubility in various solvents, impacting its behavior in complex chemical systems.