Lopinavir CAS: 192725-17-0
MF: C37H48N4O5
MW: 628.80
An HIV-1 protease inhibitor.

Lopinavir (CAS 192725-17-0)

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同义词: ABT-378
应用; An HIV-1 protease inhibitor
CAS号码: 192725-17-0
纯度: ≥99%
分子量: 628.80
分子式: C37H48N4O5
* 参考分析证明 大量特定数据 (包括水 含量).
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Lopinavir is an antiretroviral of the protease inhibitor class. Inhibition of HIV-1 protease prevents cleavage of the viral polyprotein precursor and results in the release of immature, noninfectious virions. A component of combination therapy to treat HIV/AIDS.


参考文献

Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998), Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999), Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)

外观 :
Crystalline
物理状态 :
Solid
溶解度 :
Soluble in DMF (~14 mg/ml), methanol, DMSO (126 mg/ml at 25° C), water (< 1 mg/ml at 25° C), and ethanol (126 mg/ml at 25° C).
保存 :
Store at 4° C
熔点 :
124-127° C
沸点 :
~924.2° C at 760 mmHg (Predicted)
密度 :
~1.2 g/cm3 (Predicted)
折射率 :
n20D 1.58 (Predicted)
IC50 :
Human immunodeficiency virus 1: IC50 = 1 nM; Human immunodeficiency virus 2: IC50 = 4 nM; MT4: IC50 = 35 nM (human); Human immunodeficiency virus: IC50 = 40 nM; Mdr-1: IC50 = 1.7 µM (human)
Ki 数据 :
Human immunodeficiency virus type 1 protease: Ki= 1.3 pM (Human immunodeficiency virus 1); CYP3A4: Ki= 410 nM (human); mutant HIV protease V82T: Ki= 3.6 pM; mutant HIV protease V82F: Ki= 3.7 pM; mutant HIV protease V82A: Ki= 4.9 pM
pK值 :
pKa: 13.89 (Predicted)
仅供科研使用。不可用于诊断或治疗。
RTECS :
UV6264135
PubChem CID :
92727
MDL 号码 :
MFCD22373646
SMILES :
CC1=C(C(=CC=C1)C)OCC(=O)N[[email protected]@H](CC2=CC=CC=C2)[[email protected]](C[[email protected]](CC3=CC=CC=C3)NC(=O)[[email protected]](C(C)C)N4CCCNC4=O)O

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PMID: # 31133852  Bresciani, E. et al. 2019. Front Pharmacol. 10: 461.

PMID: # 26824902  Hampson, L. et al. 2016. PLoS ONE. 11: e0147917.

PMID: # 25988960  Zhu, Q. et al. 2015. Sci Rep. 5: 10323.

PMID: # 21068005  Leroyer, S. et al. 2011. J. Lipid Res. 52: 207-20.

PMID: # 20884875  Lefèvre C et al. 2010. Arterioscler Thromb Vasc Biol. 30: 2611-2620.

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