SPTLC3 Inhibitors

SPTLC3 inhibitors are chemical compounds that inhibit Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3). SPTLC3 is a subunit of the serine palmitoyltransferase (SPT) enzyme complex, which plays a pivotal role in sphingolipid metabolism by catalyzing the first step in the synthesis of these important lipids. The regulation of sphingolipid synthesis is crucial as these lipids are key components of cell membranes and are involved in various cellular functions, including signal transduction and cell-cell interactions. Inhibitors of SPTLC3 specifically interact with this subunit, thereby influencing the overall activity of the SPT complex.