SPT7L Inhibitors
SPT7L inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of the SPT7-like (SPT7L) protein, a member of the SAGA (Spt-Ada-Gcn5-acetyltransferase) complex involved in chromatin remodeling and transcriptional regulation. SPT7L is integral to the structural and functional integrity of the SAGA complex, which plays a crucial role in histone acetylation, thereby influencing gene expression. Through its involvement in chromatin remodeling, SPT7L helps regulate the accessibility of DNA to transcriptional machinery, impacting processes such as gene activation, repression, and overall transcriptional dynamics. By inhibiting SPT7L, these compounds disrupt the assembly or activity of the SAGA complex, leading to alterations in chromatin structure and transcriptional control.
The mechanisms of SPT7L inhibitors typically involve binding to the SPT7L protein, preventing its interaction with other components of the SAGA complex or hindering its role in chromatin modification. Some inhibitors may target the protein's ability to assist in histone acetyltransferase activity or to facilitate the recruitment of transcription factors to gene promoters. Researchers use SPT7L inhibitors to study the regulation of gene expression and chromatin remodeling, as these processes are fundamental to cellular function and development. By blocking SPT7L activity, scientists can dissect the role of the SAGA complex in transcriptional regulation and explore how chromatin remodeling affects genome accessibility and the regulation of specific genes. This research is critical for understanding the broader implications of chromatin dynamics in cellular growth, differentiation, and response to environmental signals.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Inhibits histone deacetylase, potentially altering chromatin structure and affecting the gene expression regulated by SPT7L. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Inhibits DNA methyltransferase, potentially affecting DNA methylation status and gene expression patterns involving SPT7L. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Inhibits the proteasome, potentially resulting in an accumulation of regulatory proteins that interact with SPT7L. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K, potentially disrupting signaling cascades that modulate SPT7L activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, potentially affecting protein synthesis pathways that SPT7L may regulate. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits p38 MAPK, potentially affecting stress response signaling pathways involving SPT7L. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibits MEK1/2, potentially affecting MAPK/ERK pathway that could intersect with SPT7L's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, potentially modulating stress response and apoptosis pathways involving SPT7L. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits PI3K, potentially affecting signaling pathways and subsequent protein interactions with SPT7L. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Inhibits the proteasome, potentially leading to altered protein degradation pathways involving SPT7L. | ||||||