SPOCD1 Inhibitors
Chemical inhibitors of SPOCD1 target various signaling pathways to modulate its activity. Staurosporine, a broad-spectrum protein kinase inhibitor, can impede the kinase-dependent activation of SPOCD1 through its action on multiple kinases, which might be crucial for the phosphorylation state and activity of SPOCD1. Similarly, Bisindolylmaleimide I focuses on Protein Kinase C (PKC), and by inhibiting PKC, it can prevent the phosphorylation and subsequent activation of SPOCD1. LY294002 and Wortmannin, both specific inhibitors of PI3K, can affect the phosphorylation and activity of downstream targets relevant to SPOCD1 activity. Inhibition of PI3K by these chemicals can decrease the functional activity of SPOCD1 by disrupting the PI3K pathway.
Further to these, PD98059 and U0126, selective inhibitors of MEK, along with LY3214996, an ERK1/2 inhibitor, can disrupt the MAPK pathway, which is often involved in the regulation of transcriptional activity. By inhibiting MEK or ERK, these chemicals can alter the functional state of SPOCD1, assuming it relies on the MAPK signaling for its activation. SB203580 and SP600125 target the p38 MAP kinase and JNK, respectively, other components of the MAPK pathway. The inhibition of these kinases can lead to decreased SPOCD1 activity if it is regulated by these specific signaling routes. Rapamycin, an inhibitor of mTOR, can interfere with the activity of SPOCD1 by disrupting the PI3K/AKT/mTOR signaling pathway, which has roles in the regulation of transcription. MG132, a proteasome inhibitor, can increase the levels of ubiquitinated proteins, possibly including those that regulate SPOCD1, thereby indirectly affecting its activity. Lastly, PF-477736 inhibits checkpoint kinase 1 (Chk1), which can reduce the functional activity of SPOCD1 if Chk1 activity is needed for its regulation. Each of these chemicals, by inhibiting specific kinases or pathways, can affect the regulatory mechanisms that control the activity of SPOCD1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. SPOCD1, being involved in transcriptional regulation, likely interacts with protein kinase signaling pathways for its activity regulation. Staurosporine inhibits these kinases, thereby potentially inhibiting the kinase-dependent activation of SPOCD1. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I specifically inhibits Protein Kinase C (PKC). As SPOCD1 might be regulated by PKC-mediated phosphorylation, inhibition of PKC can lead to the functional inhibition of SPOCD1 activity by preventing its necessary phosphorylation state. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. PI3K pathway is linked to the regulation of transcription factors. Inhibition of PI3K can lead to reduced phosphorylation of downstream targets that may be required for SPOCD1 functional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which is upstream of ERK in the MAPK pathway. SPOCD1, as a transcriptional regulator, may rely on the MAPK pathway for functional activation. Inhibition of MEK thus inhibits the ERK pathway, potentially inhibiting SPOCD1 activation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor, which prevents the activation of ERK. By inhibiting MEK, U0126 can disrupt the MAPK pathway, potentially leading to the functional inhibition of SPOCD1 if its activity is associated with ERK signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase. If SPOCD1 requires p38 MAP kinase signaling for its activity, then SB203580 would inhibit this signaling pathway, leading to functional inhibition of SPOCD1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of JNK. The JNK pathway can regulate transcription factors, and if SPOCD1 activity is dependent on JNK signaling, inhibition by SP600125 could result in functional inhibition of SPOCD1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. Inhibition of PI3K can affect the phosphorylation and activity of several downstream proteins, potentially leading to the inhibition of SPOCD1 if its activity relies on PI3K signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is a central component of the PI3K/AKT/mTOR pathway. As mTOR can regulate cellular transcription processes, inhibition by Rapamycin can result in the functional inhibition of SPOCD1 if it is involved in this pathway. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor. By inhibiting proteasome activity, MG132 can increase the cellular concentration of ubiquitinated proteins, which may include regulatory proteins that control SPOCD1 activity, leading to its functional inhibition. | ||||||