SPEN Activators
The class of SPEN Activators refer to a specific class of chemical compounds that have garnered attention in the field of molecular biology and cellular research due to their role in modulating the SPEN (Split Ends) protein. The SPEN protein, also known as SHARP (SMRT and HDAC-associated repressor protein) in humans, serves as a multifunctional transcriptional regulator. SPEN Activators are organic molecules designed to influence the activity of the SPEN protein, which in turn, can have a significant impact on gene expression and cellular processes.
These activators typically function by binding to specific regions of the SPEN protein or its associated partners, leading to conformational changes that either enhance or suppress its transcriptional repressive activity. Through this interaction, SPEN Activators can fine-tune gene expression profiles within a cell. Researchers have been particularly interested in understanding the mechanisms underlying SPEN Activators' effects on gene regulation, as this can provide insights into various biological processes. Furthermore, these compounds have been instrumental in deciphering the intricate networks of gene regulation and epigenetic modifications, shedding light on the complexity of cellular responses to environmental cues. SPEN Activators ability to modulate gene expression makes them valuable tools in elucidating fundamental biological processes, potentially contributing to advancements in our understanding of cellular biology and disease mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol, a natural estrogen, can indirectly enhance the activity of SPEN by engaging estrogen receptor pathways which SPEN is known to co-repress. The binding of estradiol to its receptor can lead to the dissociation of SPEN, thus enhancing its repressive activities on target genes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, can indirectly activate SPEN by increasing the acetylation of histones, leading to a more open chromatin structure. This could facilitate SPEN's ability to access and repress its target genes by altering chromatin dynamics. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, can lead to hypomethylation of DNA and indirectly enhance SPEN activity by potentially increasing the expression of genes that SPEN represses, as DNA methylation is typically associated with gene silencing. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid can indirectly enhance SPEN activity through its role in gene regulation via retinoic acid receptors. SPEN is known to interact with these receptors and may modulate gene expression patterns in response to retinoic acid signaling. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275, a class I histone deacetylase inhibitor, can enhance SPEN function indirectly by promoting a more open chromatin state, which may facilitate SPEN's gene repression activities by allowing better access to its target genomic sites. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid, another histone deacetylase inhibitor, can indirectly enhance SPEN activity by altering chromatin structure, potentially facilitating SPEN's role in gene repression by allowing it to more effectively interact with its target genes. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid, a histone deacetylase inhibitor, can indirectly enhance the activity of SPEN by promoting a chromatin state conducive to SPEN's repression of target genes, thus potentially increasing the efficacy of SPEN's regulatory functions. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX-01294, a G9a histone methyltransferase inhibitor, can indirectly enhance SPEN activity by altering histone methylation patterns, which can affect chromatin dynamics and potentially increase the accessibility of target genes to SPEN's repressive action. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108, a DNA methyltransferase inhibitor, can enhance SPEN activity by reducing DNA methylation, which may upregulate genes normally repressed by DNA methylation that SPEN also targets, thus indirectly increasing SPEN's repressive influence on these genes. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat, a histone deacetylase inhibitor, can indirectly enhance SPEN's activity by modifying the acetylation state of histones, potentially improving SPEN's ability to bind to and repress its target genes through alterations in chromatin structure. | ||||||