Speedy E2 Inhibitors
Speedy E2 inhibitors belong to a chemical class targeting a specific enzymatic pathway involved in the catalysis of a group of reactions related to the hormone estrogen. The 'E2' in their name refers to estradiol, the principal estrogen in humans, which plays a crucial role in the regulation of various physiological processes. These inhibitors are designed to interfere with the activity of enzymes that are instrumental in the synthesis or metabolism of estradiol, thereby affecting the overall bioavailability of this hormone. The chemical structure of Speedy E2 inhibitors is such that they can bind to the active site of these enzymes, or possibly to allosteric sites, which are distinct from the active site but can induce conformational changes affecting enzyme activity.
The development of Speedy E2 inhibitors involves a nuanced understanding of the enzyme's structure they aim to inhibit, including the active site's geometry, charge distribution, and the dynamic process through which the enzyme interacts with its substrates or other regulatory molecules. These inhibitors are often the product of intricate medicinal chemistry efforts, where optimizing the balance between potency, selectivity, and suitable pharmacokinetic properties is essential. The design incorporates knowledge from various fields such as organic chemistry, biochemistry, and computational modeling to predict how these molecules will interact with their target enzyme. The result is a compound that specifically binds to the enzyme, modulating its action in a precise manner. The specificity of these inhibitors is critical as it reduces the likelihood of off-target effects that can alter other physiological pathways, which is an essential consideration in the development of this chemical class.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. By inhibiting multiple kinases, it can reduce the phosphorylation of Speedy E2, which is essential for its activation and stability. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphoinositide 3-kinases (PI3K) inhibitor. PI3K signaling is crucial for various cellular processes, including those that may stabilize Speedy E2. Inhibiting PI3K can decrease Speedy E2 activity by reducing its associated signaling events. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. Inhibiting mTOR can lead to a decrease in protein synthesis including the synthesis of proteins that interact with or activate Speedy E2, therefore reducing Speedy E2 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor. By inhibiting MEK, the downstream ERK/MAPK signaling is dampened. This pathway may be involved in the post-translational modifications of Speedy E2, and thus its inhibition can decrease Speedy E2 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is also a MEK inhibitor, and it works similarly to PD98059 by reducing ERK/MAPK signaling thus potentially diminishing Speedy E2 activation or function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is a JNK inhibitor. JNK pathway is involved in various cellular stress responses and may regulate proteins that interact with Speedy E2. Inhibiting JNK could lead to a reduction in these regulatory mechanisms, decreasing Speedy E2 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. The p38 MAPK pathway can influence cellular responses that may affect Speedy E2 function. Inhibition of p38 MAPK may reduce Speedy E2 activity by altering these responses. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. It suppresses the PI3K/Akt pathway which could be involved in the regulation of Speedy E2, thus its inhibition may lead to decreased Speedy E2 activity. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. Aurora kinases can phosphorylate substrates that interact with or regulate Speedy E2. Inhibition of Aurora kinases might reduce Speedy E2 activity through these interactions. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. By inhibiting the proteasome, proteins that degrade Speedy E2 may accumulate, leading to an indirect decrease in Speedy E2 levels due to enhanced degradation. | ||||||