SPATA22 Activators

SPATA22, as a vital cog in the DNA repair machinery, can interact with and be modulated by various chemicals that target the DNA structure or DNA processing enzymes. Cisplatin, Bleomycin, MMS, Etoposide, Camptothecin, and Mitomycin C, for instance, directly interact with DNA. These agents cause different types of DNA lesions – from crosslinks to strand breaks – which in turn necessitate the involvement of repair proteins, among which SPATA22 is significant.

Furthermore, the panorama of DNA replication and repair is intricate, with various agents playing roles in inducing stress or inhibiting crucial enzymes. Hydroxyurea and Aphidicolin, for instance, stall replication forks, which can then call upon repair proteins like SPATA22. Nocodazole, by disrupting microtubule dynamics, introduces an indirect mechanism to affect related processes. On the enzyme regulation front, Olaparib, a PARP, and the ATR VE-821, both affect pivotal enzymes in DNA repair pathways. The modification of these enzyme activities creates a ripple effect across the repair landscape, possibly modulating the function or levels of SPATA22.