SPANX-N1 Inhibitors
SPANX-N1 inhibitors encompass a variety of chemical compounds that exert their inhibitory action through interference with cellular processes critical for mitotic function, where SPANX-N1 is known to play a role. Certain alkaloid agents target microtubule assembly, a key component of the mitotic spindle, which is essential for cell division and the proper function of SPANX-N1. By destabilizing the mitotic spindle, these compounds indirectly compromise the activity of SPANX-N1 during mitosis. Other inhibitors work by stabilizing microtubules and preventing their disassembly, which can adversely affect the mitotic spindle dynamics and, consequently, the activity of SPANX-N1. Furthermore, some compounds bind directly to tubulin, inhibiting microtubule polymerization, thereby disrupting the cytoskeletal organization and spindle formation that are essential for SPANX-N1's function in cell division.
Additional inhibitors operate by targeting specific proteins involved in mitotic spindle formation and function, such as kinesin Eg5 and various kinases. For instance, by inhibiting kinesin Eg5, certain inhibitors can prevent the proper assembly of the mitotic spindle, leading to a potential inhibition of SPANX-N1. Similarly, compounds that inhibit key kinases involved in chromosome alignment and segregation can indirectly affect the localization and function of SPANX-N1 during mitosis. Cyclin-dependent kinase inhibitors also play a role, potentially leading to the inhibition of SPANX-N1 by affecting cell cycle progression and thus the mitotic processes that SPANX-N1 is implicated in.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
This alkaloid agent disrupts microtubule assembly. SPANX-N1, located in the nuclear envelope during mitosis, may have its function compromised as vinblastine destabilizes the mitotic spindle. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
By stabilizing microtubules and preventing their disassembly, taxol can affect the mitotic function, potentially influencing the activity of SPANX-N1 during cell division. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, inhibiting microtubule polymerization. This can indirectly affect SPANX-N1 by disrupting the cytoskeletal organization and mitotic spindle formation. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
As a microtubule-depolymerizing agent, nocodazole may indirectly inhibit SPANX-N1 by preventing the proper assembly of the mitotic spindle required for its function during cell division. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin interferes with microtubule function. This could lead to an inhibition of SPANX-N1 by affecting the microtubule dynamics that are essential for its function during mitosis. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
This compound inhibits the polymerization of tubulin, potentially leading to the inhibition of SPANX-N1 by disrupting microtubule formation and thus affecting the cellular division process. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor that disrupts mitotic spindle formation. SPANX-N1, associated with the nuclear envelope, may be indirectly inhibited through impaired spindle dynamics. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
This Plk1 inhibitor can alter the progression of mitosis, potentially affecting the function of SPANX-N1 by disrupting the phosphorylation events required for its role during cell division. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
As an Aurora kinase inhibitor, ZM-447439 could indirectly inhibit SPANX-N1 by interfering with chromosome alignment and segregation during mitosis, where SPANX-N1 is localized. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
This cyclin-dependent kinase inhibitor may inhibit SPANX-N1 indirectly by affecting cell cycle progression and thus the mitotic processes in which SPANX-N1 is implicated. | ||||||