SOSTDC1 Inhibitors
SOSTDC1 inhibitors belong to a distinctive chemical class that specifically targets the protein Sclerostin and its domain-containing homolog 1 (SOSTDC1). Sclerostin is a secreted glycoprotein that plays a crucial role in the regulation of bone formation and homeostasis. SOSTDC1, also known as Wise (Wnt modulator in surface ectoderm), shares sequence homology with Sclerostin and operates as an antagonist of bone morphogenetic proteins (BMPs) and Wnt signaling pathways. The inhibitors designed for SOSTDC1 target the functional domains of this protein to modulate its activity, thereby influencing the intricate balance between bone formation and resorption.
The chemical structures of SOSTDC1 inhibitors are meticulously designed to interact with specific binding sites on the protein, disrupting its ability to inhibit osteoblastic activity. These inhibitors are characterized by their high selectivity for SOSTDC1, distinguishing them from compounds targeting related pathways. Understanding the structural nuances of SOSTDC1 has paved the way for the rational design of small molecules capable of interfering with its regulatory function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that can modulate the Wnt pathway by inhibiting GSK-3β, which stabilizes β-catenin, thereby decreasing Wnt signaling. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1-endo stabilizes Axin by inhibiting the tankyrase enzymes, leading to reduced β-catenin levels and downregulation of Wnt signaling. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV-939 is a tankyrase inhibitor that promotes the stabilization of Axin and leads to the degradation of β-catenin, attenuating Wnt signaling. | ||||||
JW 55 | 664993-53-7 | sc-364517 sc-364517A | 10 mg 50 mg | $172.00 $726.00 | ||
JW55 acts as an antagonist of the Wnt/β-catenin signaling pathway by inhibiting the PARP domain of tankyrase 1 and 2, leading to Axin stabilization and β-catenin degradation. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
FH535 is a dual inhibitor of β-catenin/Tcf4 and PPAR, leading to downregulation of Wnt signaling and derepression of PPAR target genes. | ||||||
KY02111 | 1118807-13-8 | sc-397043 sc-397043A | 5 mg 25 mg | $79.00 $336.00 | ||
KY02111 promotes the degradation of β-catenin by disrupting the interaction between Wnt ligands and their receptors, downregulating Wnt signaling. | ||||||
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $228.00 $422.00 | ||
Pyrvinium pamoate modulates the Wnt pathway by activating casein kinase 1α, which promotes β-catenin phosphorylation and degradation. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $162.00 $241.00 $406.00 $474.00 | 1 | |
Salinomycin can inhibit Wnt signaling by selectively killing Wnt-dependent cancer stem cells, reducing pathway activity. | ||||||
Cardamonin | 19309-14-9 | sc-293984 sc-293984A | 10 mg 50 mg | $224.00 $940.00 | ||
Cardamonin inhibits the Wnt/β-catenin signaling pathway by suppressing the phosphorylation of LRP6 and increasing the phosphorylation of β-catenin. | ||||||