SNED1 Inhibitors
Chemical inhibitors of SNED1 can influence its function through various pathways within the cell. Rapamycin, a well-known inhibitor of the mTOR pathway, binds to FKBP12 and the resulting complex directly inhibits mTOR signaling, a pathway that SNED1 interacts with. This inhibition leads to a decrease in protein synthesis and cellular proliferation, processes in which SNED1 plays a part. Similar to Rapamycin, PP242 and AZD8055 are selective mTOR inhibitors that target both mTORC1 and mTORC2 complexes, thereby suppressing the activity of SNED1 associated with cell growth, angiogenesis, and metabolism. Palomid 529 (P529) and Torin 1 also inhibit the mTOR/Akt pathway, reducing the impact of SNED1 on cell migration and adhesion. Wortmannin and LY294002 are both PI3K inhibitors; with PI3K signaling being upstream of mTOR, their action can decrease mTOR activity, which is closely tied to SNED1's role in cell growth and survival.
Further targeting the MAPK/ERK pathway, which SNED1 is involved in, U0126 and PD98059 are inhibitors of MEK1/2, leading to decreased activation of ERK and thus a reduction in SNED1-mediated cellular signaling related to proliferation and differentiation. SP600125 and SL327 inhibit the JNK and MEK components of the MAPK pathway, respectively, which can lead to a decrease in the SNED1's functional activity in processes such as cell matrix remodeling and migration. SB203580 specifically inhibits p38 MAPK, impacting SNED1's role in the cellular response to stress, including inflammation and apoptosis.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to FKBP12 and the complex inhibits the mTOR pathway, which SNED1 is known to interact with. Inhibition of mTOR signaling can lead to reduced protein synthesis and cellular proliferation, processes in which SNED1 is implicated. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K signaling is upstream of the mTOR pathway, which SNED1 is involved with. By inhibiting PI3K, LY294002 can decrease mTOR activity, subsequently reducing SNED1-related processes, such as cell migration and adhesion. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are kinases in the MAPK/ERK pathway. SNED1 is part of the signaling processes involving MAPK/ERK. Inhibition of MEK1/2 by U0126 can lead to decreased ERK activation and thus decrease the functional influence of SNED1 in cellular signaling related to proliferation and differentiation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAPK pathway, which is linked to SNED1. By inhibiting JNK, SP600125 can reduce the functional activity of SNED1 in processes such as cell matrix remodeling and migration. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. The p38 MAPK pathway is involved in stress responses and is associated with SNED1. Inhibition of p38 MAPK by SB203580 can therefore impede SNED1's role in cellular response to stress, including inflammation and apoptosis. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor, and by inhibiting PI3K, it can reduce mTOR activity. Since SNED1 is involved with mTOR signaling, wortmannin can suppress SNED1's function in cell growth and survival. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is a selective mTOR inhibitor that directly inhibits both mTORC1 and mTORC2 complexes. As SNED1 interacts with mTOR signaling, inhibition by PP242 can lead to a decrease in SNED1 function related to cell growth and angiogenesis. | ||||||
Palomid 529 | 914913-88-5 | sc-364563 sc-364563A | 10 mg 50 mg | $300.00 $1000.00 | ||
Palomid 529 (P529) inhibits the mTOR/Akt pathway, which is related to SNED1's role in cell migration and adhesion. By inhibiting this pathway, P529 can decrease the functional impact of SNED1. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is an mTOR inhibitor that can block both mTORC1 and mTORC2. Since SNED1 is associated with mTOR signaling, inhibition by Torin 1 can impact SNED1's functional role in processes such as cellular proliferation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, which indirectly decreases ERK activity. Given that SNED1 is part of the signaling cascade involving ERK, PD98059 can inhibit SNED1's function in cell differentiation and proliferation. | ||||||