SLIT-ROBO Rho GTPase activating protein (SRGAP) Inhibitors
The SLIT-ROBO Rho GTPase activating protein (SRGAP) signaling pathway plays a crucial role in various cellular processes. It is primarily involved in axon guidance and neuronal migration, essential for proper brain development. This signaling pathway is activated when SLIT proteins bind to ROBO receptors, leading to the activation of SRGAPs. Upon activation, SRGAPs modulate the activity of Rho GTPases, which are key regulators of the actin cytoskeleton. This regulation influences cell shape, migration, and neuronal connections, highlighting the pathway's importance in neurodevelopment and potentially in neurodevelopmental disorders.
Targeting the SLIT-ROBO Rho GTPase activating protein (SRGAP) for disruption or inhibition involves interfering with a critical pathway in neuronal development and cell migration. This can be achieved by targeting the interaction between SLIT ligands and ROBO receptors, thereby the activation of SRGAP proteins. Alternatively, inhibition can focus on the downstream effectors of SRGAP, particularly the Rho family of GTPases, to disrupt the actin cytoskeleton regulation
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A well-known inhibitor of ROCK (Rho-associated protein kinase), which is a downstream effector of Rho. By inhibiting ROCK, Y-27632 indirectly affects Rho GTPase signaling. | ||||||
Rhosin | 1173671-63-0 | sc-507401 | 25 mg | $555.00 | ||
This compound selectively inhibits Rho by stabilizing the GDP-bound inactive form of Rho GTPases. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
Though not a direct inhibitor of Rho, it inhibits Cdc42, a member of the Rho family GTPases, and can indirectly affect Rho signaling pathways. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $209.00 $872.00 | 12 | |
A small molecule that binds to Rac1 and inhibits its activation. EHT 1864 stabilizes Rac1 in an inactive state, preventing its interaction with downstream effectors. | ||||||
CASIN | 425399-05-9 | sc-397016 | 10 mg | $460.00 | 1 | |
While initially identified as a Cdc42 inhibitor, CASIN also affects Rac1 activity by inhibiting its GEF-mediated activation. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
This compound inhibits Rac1 by targeting its interaction with a specific GEF, Cdc42/Rac1 interactive binding motif-containing protein 1 (CIB1). | ||||||