SLIRP Inhibitors
SLIRP inhibitors belong to a class of chemical compounds that have garnered interest in the fields of molecular biology and pharmacology due to modulating specific cellular processes. SLIRP, or SRA stem-loop interacting RNA-binding protein, is a protein known for its interactions with specific types of RNA molecules, including non-coding RNAs. SLIRP is primarily localized within the mitochondria, the cellular organelles responsible for energy production and various metabolic processes. Within the mitochondria, SLIRP plays a crucial role in regulating the expression and stability of mitochondrial-encoded RNA molecules, which are essential for mitochondrial protein synthesis and function. SLIRP inhibitors are designed to interact with the active site or binding domain of the SLIRP protein, effectively inhibiting its function and influencing cellular processes dependent on SLIRP-mediated mitochondrial RNA regulation and mitochondrial function.
Structurally, SLIRP inhibitors are engineered to selectively target the active site or binding domains of SLIRP, ensuring high specificity for this particular RNA-binding protein within the mitochondria. By inhibiting SLIRP, these compounds may disrupt its role in mitochondrial RNA stability and expression, leading to alterations in mitochondrial protein synthesis and mitochondrial function. The study of SLIRP inhibitors is of significant interest to researchers as it provides insights into the regulatory mechanisms governing essential cellular functions related to mitochondrial biogenesis, metabolism, and energy production. This knowledge contributes to our understanding of basic cell biology and may have implications in various research areas, including mitochondrial diseases, cellular bioenergetics, and the molecular basis of conditions associated with mitochondrial dysfunction. However, further research is required to fully explore the extent of their applications and their impact on cellular physiology in the context of SLIRP-mediated mitochondrial RNA regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide has been shown to inhibit the transcription of various genes, potentially through the modulation of transcription factors and could thus lead to the downregulation of SLIRP expression within cells. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA polymerase action, which can result in the global downregulation of gene transcription, including the potential suppression of SLIRP expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin is an inhibitor of RNA polymerase II, which is responsible for mRNA synthesis. By inhibiting this enzyme, α-Amanitin could potentially decrease the expression of SLIRP by preventing its mRNA transcription. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is known to intercalate into DNA, which can disrupt DNA replication and RNA synthesis. This action may potentially downregulate the expression of certain genes, possibly including SLIRP. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to DNA, specifically at G-C rich regions, and can block transcription factor binding and RNA synthesis, which may result in decreased SLIRP gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analog of cytidine that can be incorporated into DNA and RNA. It is known to cause DNA demethylation and could potentially reduce the expression of certain genes, possibly including SLIRP. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits the DNA enzyme topoisomerase I, which is required for DNA replication. Its action can lead to a reduction in the transcription of various genes, which may include SLIRP. | ||||||
Bufalin | 465-21-4 | sc-200136 sc-200136A sc-200136B sc-200136C | 10 mg 25 mg 50 mg 100 mg | $97.00 $200.00 $334.00 $533.00 | 5 | |
Bufalin has been reported to affect cellular signaling pathways and may influence the transcriptional regulation of genes, potentially causing a decrease in the expression of SLIRP. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid is known to modulate multiple cellular signaling pathways and can affect the transcription of certain genes. Its impact on gene regulation could potentially lead to inhibited SLIRP expression. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms DNA crosslinks which can inhibit transcription and replication. This action might lead to a decrease in the transcription of various genes, potentially including SLIRP. | ||||||