Date published: 2025-10-25

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SLC2A13 Inhibitors

Chemical inhibitors of SLC2A13 function through various mechanisms to impede its ability to transport glucose across cell membranes. It achieves this by blocking the glucose transport functions that SLC2A13 typically facilitates. Similarly, chemicals like WZB117 and STF-31, which are known for their inhibitory actions on GLUT1, can also inhibit SLC2A13. They do so by hindering glucose transport, thereby reducing glucose influx mediated by SLC2A13. Furthermore, Cytochalasin B directly binds to SLC2A13, obstructing the glucose transport pathway and thus inhibit the protein's function. Moreover, BAY-876, by its nature of being a GLUT1 inhibitor, can occupy the binding sites on SLC2A13, resulting in competitive inhibition and prevention of glucose entry into the cell. Flavonoids such as Apigenin, Quercetin, and Luteolin operate by binding to the extracellular component of the transporter SLC2A13, altering its conformation and impairing glucose transport. Fasentin contributes to the inhibition of SLC2A13 by disrupting its intracellular trafficking, thus preventing its correct localization within the cell membrane which is essential for its function. The isoflavones Genistein and Daidzein also play a role in inhibiting SLC2A13. They might exert their inhibitory effect by binding directly to the transporter or by modifying its function, which in turn interferes with the protein's ability to conduct glucose molecules across the cell membrane. Resveratrol, another polyphenolic compound, can inhibit SLC2A13 by inducing conformational changes that impede the protein's glucose transport capabilities.

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Wiskostatin

253449-04-6sc-204399
sc-204399A
sc-204399B
sc-204399C
1 mg
5 mg
25 mg
50 mg
$48.00
$122.00
$432.00
$812.00
4
(1)

WZB117 is known to inhibit GLUT1, a glucose transporter protein. As SLC2A13 belongs to the same transporter family, WZB117 can inhibit SLC2A13 by hindering the glucose transport across the cell membrane, thereby decreasing the glucose influx that SLC2A13 normally mediates.

STF 31

724741-75-7sc-364692
10 mg
$183.00
3
(1)

STF-31 is a selective inhibitor of GLUT1. Its mechanism involves the obstruction of the glucose binding site on GLUT1. Since SLC2A13 is structurally similar to GLUT1 as part of the SLC2A transporter family, STF-31 can inhibit SLC2A13 by a similar mechanism, targeting the glucose binding domain.

Cytochalasin B

14930-96-2sc-3519
5 mg
$195.00
19
(1)

Cytochalasin B acts by binding to the glucose transporter and blocking the sugar transport channel. This inhibition of glucose transport can extend to SLC2A13 by blocking its ability to translocate glucose across the cell membrane.

BAY-876

1799753-84-6sc-507539
5 mg
$240.00
(0)

BAY-876 is a specific inhibitor of GLUT1. By occupying the binding sites of GLUT1, it can likewise inhibit SLC2A13 by competitive inhibition, preventing glucose from entering the binding pocket necessary for its transport function.

Apigenin

520-36-5sc-3529
sc-3529A
sc-3529B
sc-3529C
sc-3529D
sc-3529E
sc-3529F
5 mg
100 mg
1 g
5 g
25 g
100 g
1 kg
$32.00
$210.00
$720.00
$1128.00
$2302.00
$3066.00
$5106.00
22
(1)

Apigenin, a flavone found in many plants, is known to inhibit glucose uptake by SLC2A transporters. It can inhibit SLC2A13 by binding to the extracellular part of the transporter, thus altering its conformation and impairing its glucose transport ability.

Fasentin

392721-37-8sc-215012
sc-215012A
5 mg
25 mg
$125.00
$440.00
(0)

Fasentin interferes with the intracellular trafficking of glucose transporters. This could inhibit SLC2A13 by preventing its proper localization in the cell membrane, thereby reducing its glucose transport capacity.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Quercetin is a flavonoid that inhibits glucose transporters by interfering with their trafficking and membrane localization. It can inhibit SLC2A13 by similar mechanisms, therefore reducing the functional presentation of SLC2A13 on the cell surface.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein is an isoflavone that has been shown to inhibit the activity of various members of the SLC2A family by altering their transport function. This inhibition likely extends to SLC2A13, as Genistein could alter its glucose transport capacity by binding to the transporter or modifying its function through phosphorylation.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol is a polyphenolic compound that can inhibit glucose transporters. This inhibition of SLC2A13 could occur through the alteration of the conformation of the transporter, impeding its ability to facilitate the passage of glucose molecules.

Luteolin

491-70-3sc-203119
sc-203119A
sc-203119B
sc-203119C
sc-203119D
5 mg
50 mg
500 mg
5 g
500 g
$26.00
$50.00
$99.00
$150.00
$1887.00
40
(1)

Luteolin is a flavonoid known to inhibit glucose uptake by SLC2A transporters. It may inhibit SLC2A13 by binding to the transporter and blocking the glucose binding site, thus preventing its normal function in glucose transport.