Slc22a27 Inhibitors
Chemical inhibitors of solute carrier family 22, member 27 (SLC22A27) include a range of compounds that exert their inhibitory effects through competitive binding to the substrate-binding sites of the protein. Probenecid, a well-known inhibitor of renal excretion of organic anions, directly competes with substrates of SLC22A27, thereby reducing the protein's transport efficiency. Similarly, Sulfinpyrazone, by competing for the same binding sites, effectively reduces the transport activity of SLC22A27. This action is mirrored by Benzbromarone, which binds to the active site of the transporter, thereby blocking its function. Indomethacin, a drug that also serves to inhibit SLC22A27, achieves its inhibitory action through a competitive mechanism, directly interacting with the transport sites to block substrate movement.
Continuing with this theme, Ketoprofen, Ibuprofen, and Naproxen are all chemicals that inhibit solute carrier family 22, member 27 by binding to its transporter sites, which hinders the uptake and movement of organic anions across cell membranes. Diclofenac extends this inhibitory pattern by binding to the substrate interaction sites, thereby curtailing the protein's ability to facilitate transport. Flurbiprofen, following a similar mechanism, binds competitively to the active sites of SLC22A27, preventing transport of its substrates. Mefenamic acid, Piroxicam, and Phenylbutazone all contribute to the inhibition of SLC22A27 by competing with natural substrates for the transporter's binding sites, which leads to a marked decrease in the protein's transport activity. These inhibitors, through their individual actions, collectively contribute to the inhibition of SLC22A27 by obstructing the transporter's substrate-binding capacity and reducing its overall function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Probenecid inhibits the renal excretion of organic anions and reduces tubular reabsorption, thereby inhibiting solute carrier family 22 member 27 by competing for its substrate-binding sites and reducing its transport efficiency. | ||||||
(±)-Sulfinpyrazone | 57-96-5 | sc-202822 sc-202822A | 1 g 5 g | $42.00 $94.00 | 2 | |
Sulfinpyrazone inhibits the activity of solute carrier family 22 member 27 by competitively blocking its substrate-binding sites, which reduces the transport of uric acid and other organic anions. | ||||||
Benzbromarone | 3562-84-3 | sc-233934 sc-233934A | 1 g 5 g | $53.00 $223.00 | ||
Benzbromarone inhibits solute carrier family 22 member 27 by binding to the transporter's active site, thereby preventing the cellular uptake of its substrates. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin inhibits solute carrier family 22 member 27 through competitive inhibition, by binding to the transport sites of the protein and blocking the transport of organic anions. | ||||||
Ketoprofen | 22071-15-4 | sc-205359 sc-205359A | 5 g 25 g | $126.00 $339.00 | 2 | |
Ketoprofen inhibits solute carrier family 22 member 27 by competitively binding to the transporter, preventing the uptake of endogenous and exogenous organic anions. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
Ibuprofen inhibits solute carrier family 22 member 27 by competing with the natural substrates for the binding sites on the transporter, thereby decreasing the transport function. | ||||||
Naproxen | 22204-53-1 | sc-200506 sc-200506A | 1 g 5 g | $24.00 $41.00 | ||
Naproxen acts as an inhibitor of solute carrier family 22 member 27 by blocking the binding sites for organic anion substrates, which inhibits the transport activity of the protein. | ||||||
Diclofenac acid | 15307-86-5 | sc-357332 sc-357332A | 5 g 25 g | $109.00 $298.00 | 5 | |
Diclofenac inhibits solute carrier family 22 member 27 by binding to its substrate interaction sites, reducing the protein's ability to transport organic anions across the cell membrane. | ||||||
Flurbiprofen | 5104-49-4 | sc-202158 sc-202158A | 100 mg 1 g | $70.00 $106.00 | ||
Flurbiprofen inhibits solute carrier family 22 member 27 through competitive inhibition, preventing the transport of various substrates by binding to the active sites of the protein. | ||||||
Mefenamic acid | 61-68-7 | sc-205380 sc-205380A | 25 g 100 g | $106.00 $208.00 | 6 | |
Mefenamic acid inhibits solute carrier family 22 member 27 by competing with organic anions for the transporter's binding sites, leading to reduced transport activity. | ||||||