SIRT5 Activators
The class of chemicals identified as SIRT5 activators includes a range of compounds, primarily natural polyphenols and flavonoids, that are known for their ability to modulate various cellular pathways, influencing SIRT5 activity. These activators do not directly interact with SIRT5 but are thought to modulate the cellular environment in a way that could enhance SIRT5's activity. One primary mechanism through which these compounds may activate SIRT5 involves the modulation of cellular stress responses and metabolic pathways. Compounds like Resveratrol, Pterostilbene, and Oleuropein are known for their roles in enhancing antioxidant responses and improving mitochondrial function. By influencing these pathways, they could indirectly activate SIRT5, which is involved in regulating oxidative stress and metabolism. Additionally, the availability of NAD+, a crucial cofactor for sirtuin activity, is a key factor in SIRT5 activation. Increasing cellular NAD+ levels, through diet or supplements, could enhance SIRT5 activity.
Another aspect of SIRT5 activation by these compounds is their role in influencing cellular aging processes. Autophagy, a cellular process involved in the degradation and recycling of cellular components, is an important aspect of aging and metabolism. Compounds like Spermidine, which induce autophagy, could indirectly activate SIRT5 by enhancing autophagic processes that SIRT5 regulates. The effectiveness of these compounds in activating SIRT5 depends on various factors, including the specific cellular context, the concentration and duration of exposure, and the presence of other interacting molecules. While these compounds provide valuable insights into the regulation of SIRT5 activity, their role in specifically modulating SIRT5-mediated processes warrants further experimental investigation in relevant biological models.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound, is known to activate sirtuins indirectly. It may enhance SIRT5 activity by modulating cellular stress responses and metabolic pathways that are regulated by SIRT5. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is a coenzyme essential for sirtuin activity. Increasing cellular NAD+ levels can indirectly activate SIRT5 by providing the necessary cofactor for its enzymatic activities. | ||||||
Pterostilbene, Pterocarpus marsupium | 537-42-8 | sc-203223 sc-203223A | 10 mg 100 mg | $207.00 $1173.00 | ||
Pterostilbene, similar to resveratrol, is a natural dietary compound that can activate sirtuins. Its effect on SIRT5 might involve modulation of metabolic pathways and enhancement of stress response mechanisms. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine, a polyamine, is known to induce autophagy and can influence sirtuin activity. It may indirectly activate SIRT5 by enhancing autophagic processes that regulate cellular metabolism and aging. | ||||||
Oleuropein | 32619-42-4 | sc-286622 sc-286622A sc-286622B sc-286622C | 500 mg 1 g 10 g 100 g | $352.00 $520.00 $775.00 $6640.00 | 2 | |
Oleuropein, a component of olive oil, has been shown to activate sirtuins. Its influence on SIRT5 could involve modulation of metabolic pathways and improvement of mitochondrial function. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $51.00 $77.00 $102.00 $153.00 $2856.00 | 7 | |
Fisetin, a flavonoid, is reported to have sirtuin-activating properties. It could activate SIRT5 indirectly by modulating cellular antioxidant responses and metabolism. | ||||||
Isoliquiritigenin | 961-29-5 | sc-255222 | 10 mg | $310.00 | 1 | |
Isoliquiritigenin, a flavonoid found in licorice, has potential sirtuin-modulating activity. It may activate SIRT5 by influencing pathways involved in stress response and metabolism. | ||||||
Honokiol | 35354-74-6 | sc-202653 sc-202653A | 10 mg 25 mg | $118.00 $178.00 | 4 | |
Honokiol, a compound found in Magnolia bark, has been suggested to activate sirtuins. Its effect on SIRT5 might involve the modulation of cellular stress responses and metabolic regulation. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol, a natural flavonoid, may have sirtuin-activating effects. It could indirectly activate SIRT5 by influencing cellular antioxidant mechanisms and metabolic processes. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin, a flavonoid found in many plants, has been suggested to modulate sirtuin activity. It may indirectly activate SIRT5 by affecting cellular pathways related to metabolism and aging. | ||||||