SIRT4 Inhibitors
SIRT4 inhibitors represent a distinct category within the realm of chemical compounds that target specific proteins involved in cellular processes. SIRT4, or Sirtuin 4, is a mitochondrial enzyme classified as a member of the sirtuin family of proteins. These enzymes, often referred to as class III histone deacetylases (HDACs), play a crucial role in regulating various cellular functions, including metabolism, DNA repair, and stress response. SIRT4, in particular, is primarily located in the mitochondria, where it exerts control over key metabolic pathways. It functions as an ADP-ribosyltransferase and has been implicated in the regulation of glucose and fatty acid metabolism, making it an attractive target for modulation through inhibitors.
SIRT4 inhibitors, as the name suggests, are compounds designed to hinder or suppress the activity of SIRT4. By interfering with the enzymatic activity of SIRT4, these inhibitors have the ability to influence cellular processes associated with mitochondrial metabolism. The development and study of SIRT4 inhibitors are of particular interest to researchers in the field of molecular biology and biochemistry, as they provide valuable tools to dissect the intricate roles of SIRT4 in cellular homeostasis and to explore its relevance in various physiological and pathological conditions. Understanding the mechanisms of action and specificity of SIRT4 inhibitors is crucial for unraveling the complex regulatory networks in which SIRT4 participates, shedding light on its contribution to cellular processes beyond metabolic control.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide is a form of vitamin B3 and is a known inhibitor of sirtuin activity. By acting as an alternative substrate, it competitively inhibits the binding of NAD+, which is essential for sirtuin function, including SIRT4. This can lead to a decrease in SIRT4 activity, thereby potentially inhibiting its expression in the long term. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin is a polysulfonated naphthylurea compound. It has been found to inhibit the activity of various enzymes, including sirtuins. The compound interferes with protein-protein interactions and cofactor binding, which can result in the downregulation of SIRT4 expression. | ||||||
EX 527 | 49843-98-3 | sc-203044 | 5 mg | $87.00 | 32 | |
EX-527 is a selective inhibitor of SIRT1, a protein closely related to SIRT4. It acts by binding to the catalytic site of the enzyme, inhibiting its activity. While it primarily targets SIRT1, it may also have off-target effects on other sirtuin proteins, including SIRT4, potentially leading to reduced expression levels. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $38.00 $113.00 | 14 | |
Sirtinol is a known inhibitor of sirtuin activity, particularly SIRT1 and SIRT2. Its mechanism of action involves binding to the NAD+ binding site of the enzyme, leading to inhibition. Given the structural similarities among sirtuins, it is plausible that Sirtinol may also affect SIRT4, leading to decreased expression. | ||||||
Splitomicin | 5690-03-9 | sc-358701 | 5 mg | $48.00 | ||
Splitomicin is a pyrimidine derivative that inhibits sirtuin activity. While it has higher affinity for SIRT2, its inhibitory effects can extend to other sirtuins, including SIRT4. It binds to the enzyme’s catalytic domain, disrupting its function and potentially leading to decreased expression. | ||||||
Salermide | 1105698-15-4 | sc-224276 sc-224276A | 5 mg 10 mg | $70.00 $105.00 | 3 | |
Salermide is a compound that inhibits sirtuins by binding to the catalytic domain of the enzyme, impeding its activity. While its effects are more pronounced on SIRT1 and SIRT2, it may also have inhibitory effects on SIRT4, potentially leading to a reduction in protein expression levels. | ||||||
SIRT2 Inhibitor, AGK2 | 304896-28-4 | sc-202813A sc-202813 sc-202813B sc-202813C | 1 mg 5 mg 10 mg 25 mg | $46.00 $148.00 $316.00 $490.00 | 5 | |
AGK2 is a selective SIRT2 inhibitor. It binds to the active site of the enzyme, inhibiting its activity. Given the structural similarities among sirtuins, it is plausible that AGK2 may also affect SIRT4 activity, potentially leading to reduced expression levels. | ||||||
SIRT1/2 Inhibitor IV, Cambinol | 14513-15-6 | sc-204280 | 5 mg | $145.00 | 4 | |
Cambinol is a compound that inhibits sirtuin activity, with a preference for SIRT1 and SIRT2. It binds to the NAD+ binding site, leading to enzyme inhibition. Its inhibitory effects may extend to SIRT4, potentially resulting in decreased expression. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a cyclin-dependent kinase inhibitor that also has inhibitory effects on sirtuins. While its primary target is CDKs, it may bind to the catalytic site of SIRT4, leading to decreased enzyme activity and potentially a reduction in protein expression levels. | ||||||