Suramin sodium CAS: 129-46-4
MF: C51H34N6O23S6•6Na
MW: 1429.17
A G protein uncoupler and inhibitor of PDGF, EGF, TGFb, SIRT1 and SIRT5.

Suramin sodium (CAS 129-46-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 166ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
5
1
4
0
3
0
2
0
1
0
Sinônimo Suramine sodium salt
Aplicação A G protein uncoupler and inhibitor of PDGF, EGF, TGFb, SIRT1 and SIRT5
Numero VAT: 129-46-4
Privada: ≥98%
Peso Molecular: 1429.17
Separar por Funcao: C51H34N6O23S66Na
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
Faça a sua avaliação desse produto e receba 15 CruzCredits

Suramin Sodium uncouples G proteins from receptors by blocking their interaction with intracellular, P2X and P2Y, purinergic receptor domains. The compound also inhibits the cell surface binding of various growth factors including PDGF, FGF-2 (FGFb), FGF-1 (FGFa), EGF and TGF-β. It is a potent competitive inhibitor of reverse transcriptase and protects T lymphocytes against in vitro human immunodeficiency virus infection. Suramin Sodium has been observed as a potent inhibitor of melanoma HPA (heparanase) and tumor cell metastasis. Inhibition of NAD+-dependent deacetylase SIRT1 with an IC50 of 2.6 μM along with SIRT5 has also been observed. Suramin Sodium has been recorded to antagonize EDG-3 (S1P3) selectively. Suramin Sodium is an inhibitor of A cyclase, FGF-1, FGF-2, IL-1, IL-4, PDGF, PC-PLD, PKC, SH-PTP, TERT, TGF beta 1, Topo I, Topo II and VEGF.


Referencias

1. De Clercq, E. 1979. Cancer Lett. 8: 9-22. PMID: 92362
2. Mitsuya, H., et al. 1984. Science. 226: 172-174. PMID: 6091268
3. Hosang, M. 1985. J. Cell. Biochem. 29: 265-273. PMID: 4077932
4. Betsholtz, C., et al. 1986. Proc. Natl. Acad. Sci. U.S.A. 83: 6440-6444. PMID: 3018732
5. Coffey, R.J., et al. 1987. J. Cell. Physiol. 132: 143-148. PMID: 3496343
6. Kopp, R. and Pfeiffer, A. 1990. Cancer Res. 50: 6490-6496. PMID: 2170005
7. Huang, R.R., et al. 1990. Mol. Pharmacol. 37: 304-310. PMID: 2154676
8. Nakajima, M., et al. 1991. J. Biol. Chem. 266: 9661-9666. PMID: 2033058
9. Ancellin, N. and Hla, T. 1999. J. Biol. Chem. 274: 18997-19002. PMID: 10383399

Estado físico :
Solid
envie :
Soluble in water (50 mg/mL), 95% ethanol, and DMSO (10 mM). Insoluble in benzene, ether, and chloroform.
Manutencao :
Store at room temperature
IC50 :
Trypanosoma brucei: IC50 = 43 nM
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
RTECS :
QM7000000
PubChem CID :
8514
Indice de produtos :
14: 9006
Numero de FAX :
MFCD00210217
Numero de FAX :
204-949-3
SMILES :
CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

Baixar SDS (MSDS)

Certificado de Análise

É necessário o Adobe Acrobat Reader para visualizar corretamente,
imprimir e comentar os documentos PDF

Suramin sodium  Citacoes dos Produtos

Visualizar com outras pessoas usaram Suramin sodium. Clique em PubMed para ver .

Citações 1 para 6 de 6 total

PMID: # 27226534  Chen, L. et al. 2016. The Journal of biological chemistry.

PMID: # 26112648  Albulescu, IC. et al. 2015. Antiviral research. 121: 39-46.

PMID: # 25989529  Torres-Fuentes, JL. et al. 2015. Journal of cellular physiology. 230: 3068-75.

PMID: # 26187851  Li, S. et al. 2015. Journal of cell science. 128: 3317-29.

PMID: # 25822366  Chen, CW. et al. 2015. Nature medicine. 21: 335-43.

PMID: # 24829459  Calderon, MR. et al. 2014. Nucleic acids research. 42: 7012-27.

Citações 1 para 6 de 6 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 132ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 35ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

A Santa Cruz Biotecnologia, Inc. é a líder mundial no desenvolvimento de produtos para o mercado de pesquisa biomédica. Ligue para nós ligação gratuita 1-800-457-3801..
Direito de Reprodução© 2007-2020 Santa Cruz Biotechnology, Inc. Todos os direitos reservados. "Santa Cruz Biotechnology", Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", "EZ Touch" são marcas registradas da Santa Cruz Biotechnology, Inc. Todas as marcas registradas são propriedade dos seus respectivos donos.