SIRT2 Inhibitors

SIRT2 inhibitors belong to a class of chemical compounds that are designed to selectively target and inhibit the function of the sirtuin 2 (SIRT2) protein. SIRT2 is a member of the sirtuin family of NAD+-dependent histone deacetylases that play a crucial role in regulating various cellular processes, including gene expression, DNA repair, and cell cycle progression. SIRT2 is primarily localized in the cytoplasm and has been implicated in the modulation of cytoskeletal dynamics, cell motility, and mitotic control. The inhibition of SIRT2 by these compounds aims to disrupt its deacetylase activity, leading to alterations in the acetylation status of its target proteins. By inhibiting SIRT2, these compounds could impact cellular processes that are regulated by SIRT2, such as microtubule dynamics, cell cycle progression, and oxidative stress response. Exploring SIRT2 inhibitors provides insights into the roles of SIRT2 in cellular functions and pathways, shedding light on its contributions to various physiological and pathological processes.