Sir2 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Splitomicin | 5690-03-9 | sc-358701 | 5 mg | $47.00 | ||
Splitomicin acts as a potent inhibitor of Sir2, engaging in specific hydrogen bonding interactions that stabilize its binding to the enzyme's active site. This compound selectively modulates the deacetylation process, influencing histone modification and gene expression. Its unique structural features allow for enhanced interaction with the NAD+ cofactor, affecting the kinetics of the enzymatic reaction. Furthermore, Splitomicin's solubility profile supports its effective diffusion across cellular membranes, impacting its interaction dynamics within cellular environments. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide competes with NAD+ for the active site on Sir2, leading to inhibition of its deacetylase activity. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $37.00 $111.00 | 14 | |
Sirtinol functions as a selective inhibitor of Sir2, characterized by its ability to disrupt the enzyme's catalytic activity through competitive binding. Its unique structural conformation facilitates specific interactions with the enzyme's active site, altering the conformational dynamics essential for substrate recognition. This compound also influences the NAD+-dependent deacetylation pathway, modulating the enzyme's reaction kinetics and impacting downstream signaling pathways. Additionally, Sirtinol's hydrophilic properties enhance its solubility, promoting its accessibility within cellular compartments. | ||||||
Dihydrocoumarin | 119-84-6 | sc-227867 sc-227867A | 5 g 25 g | $17.00 $41.00 | ||
Dihydrocoumarin acts as a modulator of Sir2, exhibiting a distinct mechanism of interaction that influences the enzyme's structural stability. Its unique lactone ring allows for non-covalent interactions with key residues in the active site, potentially altering the enzyme's affinity for NAD+. This compound may also affect the conformational flexibility of Sir2, thereby impacting its deacetylation activity and subsequent cellular processes. Its lipophilic nature aids in membrane permeability, facilitating cellular uptake. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin has been shown to non-selectively inhibit various enzymes, including Sir2, by interfering with substrate binding. | ||||||
SIRT1/2 Inhibitor IV, Cambinol | 14513-15-6 | sc-204280 | 5 mg | $142.00 | 4 | |
Cambinol selectively inhibits sirtuin activity, which can reduce the deacetylase activity of Sir2. | ||||||
EX 527 | 49843-98-3 | sc-203044 | 5 mg | $85.00 | 32 | |
EX-527 is a selective inhibitor of SIRT1, a homolog of Sir2, and can inhibit Sir2 by a similar mechanism of action. | ||||||
Salermide | 1105698-15-4 | sc-224276 sc-224276A | 5 mg 10 mg | $70.00 $105.00 | 3 | |
Salermide is a sirtuin inhibitor that can induce apoptosis by inhibiting Sir2-related deacetylation processes. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Tenovin-6 inhibits Sir2 by increasing the levels of p53, which indirectly reduces Sir2 activity by promoting cellular stress. | ||||||
SIRT2 Inhibitor, AGK2 | 304896-28-4 | sc-202813A sc-202813 sc-202813B sc-202813C | 1 mg 5 mg 10 mg 25 mg | $45.00 $145.00 $310.00 $480.00 | 5 | |
AGK2 is a selective SIRT2 inhibitor and may inhibit Sir2 by interfering with its NAD+-dependent deacetylase activity. | ||||||