Sir2 Activators

Common Sir2 Activators include, but are not limited to Resveratrol CAS 501-36-0, SRT1720 CAS 1001645-58-4, SRT 1460 CAS 925432-73-1, Quercetin CAS 117-39-5 and Fisetin CAS 528-48-3.

Sir2 Activators refer to a class of chemical compounds that are designed to interact with and modulate the activity of the Sirtuin 2 (Sir2) protein, also known as SIRT2. Sir2 is a member of the sirtuin family of NAD+-dependent deacetylases, a group of enzymes highly conserved across various species, including humans. These enzymes are involved in a wide range of cellular processes, including gene regulation, DNA repair, metabolism, and stress responses. SIRT2, in particular, has been extensively studied for its role in maintaining cellular homeostasis, especially in the context of aging and age-related diseases.

Sir2 activators work by enhancing the enzymatic activity of SIRT2. This activation can occur through various molecular mechanisms, such as direct binding to SIRT2, increasing the availability of its cofactor NAD+, or promoting conformational changes that enhance its catalytic efficiency. Once activated, SIRT2 plays a pivotal role in regulating cellular functions through the deacetylation of target proteins, including histones and transcription factors. By modifying the acetylation status of these proteins, SIRT2 can influence gene expression, chromatin structure, and various signaling pathways, ultimately impacting cellular processes and physiology. The study of Sir2 activators is essential for unraveling the intricate molecular mechanisms underlying the role of SIRT2 in cellular health and longevity.