SHISA7 Inhibitors

SHISA7 inhibitors primarily comprise compounds that indirectly influence the protein's function by modulating the activity of AMPA receptors. These AMPA receptor modulators serve as crucial gatekeepers of synaptic activity, dictating the flow of ions and influencing synaptic plasticity. Since SHISA7 is known to modulate AMPA receptor function, chemicals that target AMPA receptors can, by extension, modulate SHISA7's functional role.

For instance, Perampanel and NBQX are competitive AMPA receptor antagonists, which block the receptor and reduces excitatory neurotransmission. By blocking these receptors, these compounds can indirectly influence SHISA7's role in synaptic transmission. Non-competitive antagonists like GYKI 52466 also exhibit a similar function, but through a different mechanism. On the other hand, compounds like PEPA act as potentiators, enhancing AMPA receptor activity, which can also indirectly impact SHISA7's function by altering the receptor's state and responsiveness. Collectively, these chemicals signify the intertwining nature of protein functions in synaptic pathways.