SHD1 Inhibitors
Chemical inhibitors of SHD1 act through various mechanisms to disrupt the actin cytoskeleton, thereby inhibiting the function of SHD1, which is crucial for dendritic spine development and synaptic function. Phalloidin binds to F-actin and stabilizes it, preventing its depolymerization, thus interfering with the dynamic equilibrium necessary for the proper functioning of SHD1 in actin cytoskeleton dynamics. Similarly, Jasplakinolide also stabilizes actin filaments and promotes actin polymerization, potentially altering the dynamics of actin filaments required for SHD1's role in synaptic function. Cytochalasin D, on the other hand, impedes the elongation of actin filaments by binding to their barbed ends, which can inhibit the role of SHD1 in actin-dependent morphological processes. Swinholide A severs actin filaments, creating an additional barrier to the actin cytoskeleton organization that is central to SHD1's functions. Miuraenamide A also disrupts actin dynamics by binding to G-actin and stabilizing actin filaments, respectively, which can interfere with SHD1's involvement in the complex processes of synaptic plasticity and dendritic spine morphogenesis.
Other compounds target proteins that interact with the actin cytoskeleton and are thereby implicated in SHD1 function. Latrunculin A binds to actin monomers and inhibits their polymerization, which can disrupt SHD1's role in microfilament organization. CK-666 specifically inhibits the Arp2/3 complex, consequently impairing actin nucleation and branching, which are vital for SHD1-mediated actin cytoskeleton rearrangements. ML-7 and Blebbistatin target the actomyosin complex; ML-7 inhibits myosin light chain kinase, and Blebbistatin inhibits myosin II ATPase activity, both leading to effects on actin-myosin interaction and tension, which can impact SHD1's function in neuronal cells. Lastly, Y-27632 and Wiskostatin inhibit ROCK and N-WASP, respectively, both of which are regulators of actin polymerization and cytoskeleton structure, affecting the underlying structures crucial for SHD1's role in synaptic functions and dendritic spine development.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $229.00 | 33 | |
Phalloidin binds to F-actin, stabilizing it and preventing its depolymerization, which can inhibit SHD1's role in actin cytoskeleton dynamics since SHD1 is involved in dendritic spine development and synaptic function where actin polymerization is crucial. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A disrupts microfilament organization by binding to actin monomers, inhibiting polymerization. As SHD1 is implicated in the regulation of actin cytoskeleton, latrunculin A's action can inhibit SHD1's function in actin-dependent processes. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and induces actin polymerization. By altering the dynamics of actin filaments, it can inhibit the function of SHD1 which is implicated in synaptic function and dendritic spine morphology, processes dependent on actin structure. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D binds to the barbed ends of actin filaments, blocking polymerization and elongation. This action can inhibit SHD1's function in dendritic spine and synapse formation where actin polymerization is essential. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
CK-666 is an inhibitor of the actin-related protein 2/3 (Arp2/3) complex. By inhibiting Arp2/3, it disrupts actin nucleation and branching. Since SHD1 is associated with the regulation of the actin cytoskeleton, CK-666 can inhibit SHD1-mediated actin cytoskeleton rearrangements. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK), which is vital for actin-myosin contraction. Inhibition of MLCK can affect actin dynamics and therefore can inhibit SHD1's associated functions with actin cytoskeleton regulation in neuronal cells. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin is an inhibitor of myosin II ATPase activity, leading to a reduction in myosin II-mediated contractility. As SHD1 is involved in processes that rely on actin-myosin interactions, blebbistatin can inhibit SHD1's function in those processes. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of the Rho-associated protein kinase (ROCK), which modulates actin cytoskeleton structure. By inhibiting ROCK, Y-27632 can impact actin dynamics and consequently inhibit SHD1's role in actin cytoskeleton-dependent synaptic functions. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Wiskostatin is an inhibitor of the neuronal Wiskott-Aldrich syndrome protein (N-WASP), a regulator of actin polymerization. By inhibiting N-WASP, wiskostatin can impair actin-related processes, thus potentially inhibiting SHD1 function in neuronal spine development. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A severs actin filaments and prevents their reannealing. This action can inhibit SHD1's function by disrupting the actin cytoskeleton organization and dynamics, which are critical for SHD1-associated neuronal functions. | ||||||