Ser/Thr Protein Kinase Inhibitors
Items 141 to 150 of 284 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Kenpaullone | 142273-20-9 | sc-200643 sc-200643A sc-200643B sc-200643C | 1 mg 5 mg 10 mg 25 mg | $61.00 $153.00 $231.00 $505.00 | 1 | |
Kenpaullone is a selective inhibitor of Ser/Thr protein kinases, known for its unique ability to interfere with the ATP-binding site, thereby altering kinase activity. It exhibits distinct kinetic properties, leading to a reduction in phosphorylation of key substrates involved in cell cycle regulation. By stabilizing specific conformations of target kinases, Kenpaullone modulates critical signaling pathways, influencing cellular proliferation and differentiation processes. | ||||||
Evodiamine | 518-17-2 | sc-201479 sc-201479A | 20 mg 100 mg | $20.00 $72.00 | 2 | |
Evodiamine acts as a Ser/Thr protein kinase modulator, exhibiting a distinctive mechanism of action through allosteric regulation. Its unique molecular conformation enables it to bind at sites away from the active site, inducing conformational changes that affect substrate affinity. This modulation can enhance or inhibit kinase activity, influencing downstream signaling cascades. Additionally, Evodiamine's hydrophobic regions promote interactions with lipid membranes, potentially impacting membrane-associated kinases. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide acts as a Ser/Thr protein kinase modulator, exhibiting a unique ability to disrupt phosphorylation cascades. Its molecular interactions involve specific binding to regulatory sites, which alters the enzyme's conformational landscape. This compound influences reaction kinetics by stabilizing intermediate states, thereby affecting the activation and deactivation cycles of kinases. Its distinct structural features facilitate selective inhibition, impacting various signaling pathways and cellular processes. | ||||||
ERK Inhibitor Inhibitor | 1049738-54-6 | sc-221593 | 5 mg | $137.00 | 6 | |
ERK Inhibitor functions as a selective Ser/Thr protein kinase inhibitor, characterized by its ability to disrupt the phosphorylation cascade within the MAPK signaling pathway. It selectively binds to the active site of ERK, altering its conformation and inhibiting downstream signaling. This modulation affects various cellular processes, including growth and survival, by impacting the interaction dynamics between ERK and its substrates, ultimately influencing cellular responses to external stimuli. | ||||||
Indole-3-acetamide | 879-37-8 | sc-255213 sc-255213A | 1 g 5 g | $44.00 $198.00 | 1 | |
Indole-3-acetamide acts as a selective modulator of Ser/Thr protein kinases, characterized by its ability to engage in specific hydrogen bonding and hydrophobic interactions within the kinase active site. This compound influences the conformational dynamics of the enzyme, promoting a shift towards an inactive state. Its unique reaction kinetics allow for precise regulation of phosphorylation events, thereby affecting critical cellular signaling networks and metabolic pathways. | ||||||
Palmitoyl-DL-carnitine chloride | 6865-14-1 | sc-203176 sc-203176A | 100 mg 500 mg | $104.00 $437.00 | 3 | |
Palmitoyl-DL-carnitine chloride serves as a modulator of Ser/Thr protein kinases, distinguished by its capacity to form unique electrostatic interactions with key residues in the kinase domain. This compound alters the enzyme's structural conformation, enhancing or inhibiting substrate accessibility. Its distinct lipid-like properties facilitate membrane interactions, potentially influencing localization and activity of kinases within cellular compartments, thereby impacting signaling cascades. | ||||||
TBB | 17374-26-4 | sc-202830 sc-202830A sc-202830C sc-202830B sc-202830D | 10 mg 25 mg 50 mg 100 mg 250 mg | $245.00 $370.00 $454.00 $760.00 $1817.00 | 17 | |
TBB acts as a selective modulator of Ser/Thr protein kinases, characterized by its ability to engage in specific hydrogen bonding and hydrophobic interactions with the kinase active site. This compound can stabilize or destabilize the enzyme's conformation, affecting its catalytic efficiency. Additionally, TBB's unique structural features allow it to influence the phosphorylation state of target proteins, thereby modulating critical signaling pathways within the cell. | ||||||
Sangivamycin | 18417-89-5 | sc-204261 sc-204261A sc-204261B sc-204261C sc-204261D sc-204261E | 1 mg 10 mg 25 mg 50 mg 100 mg 250 mg | $333.00 $1348.00 $2611.00 $5212.00 $9894.00 $20298.00 | ||
Sangivamycin functions as a selective inhibitor of Ser/Thr protein kinases, exhibiting a unique ability to interact with the ATP-binding pocket of these enzymes. Its structural conformation facilitates specific van der Waals and electrostatic interactions, which can alter the enzyme's activity and substrate specificity. By influencing the phosphorylation dynamics of key proteins, Sangivamycin plays a role in regulating various cellular processes and signaling cascades. | ||||||
L-threo-Sphingosine C-18 | 25695-95-8 | sc-205363 sc-205363A | 5 mg 10 mg | $200.00 $380.00 | ||
L-threo-Sphingosine C-18 acts as a modulator of Ser/Thr protein kinases, engaging in specific interactions that influence enzyme conformation and activity. Its unique structure allows for the formation of hydrogen bonds and hydrophobic interactions within the kinase active site, potentially altering substrate affinity and phosphorylation rates. This compound can impact signaling pathways by fine-tuning the balance of kinase activity, thereby affecting cellular responses and regulatory mechanisms. | ||||||
1-Methylindole-3-carboxylic acid | 32387-21-6 | sc-253942 | 1 g | $18.00 | ||
1-Methylindole-3-carboxylic acid serves as a potent modulator of Ser/Thr protein kinases, exhibiting unique binding characteristics that enhance or inhibit kinase activity. Its aromatic structure facilitates π-π stacking interactions with key residues in the kinase domain, influencing conformational dynamics. This compound can alter phosphorylation kinetics by stabilizing specific enzyme-substrate complexes, thereby impacting downstream signaling cascades and cellular regulatory networks. | ||||||