Molecular structure of ERK Inhibitor, CAS Number: 1049738-54-6
ERK Inhibitor Inhibitor (CAS 1049738-54-6)
See product citations (6)
Alternate Names:
3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
Application:
ERK Inhibitor is a cell-permeable thiazolidinedione compound that shows anti-proliferative properties
CAS Number:
1049738-54-6
Purity:
≥95%
Molecular Weight:
328.81
Molecular Formula:
C14H16N2O3S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ERK Inhibitor is a cell-permeable thiazolidinedione compound that shows anti-proliferative properties. It binds preferentially to ERK2 with a KD of ~5 muM and prevents its interaction with protein substrates. The compound may act to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting minimal effect on ERK1/2 phosphorylation by MEK1/2.
ERK Inhibitor Inhibitor (CAS 1049738-54-6) References
- Identification of novel extracellular signal-regulated kinase docking domain inhibitors. | Hancock, CN., et al. 2005. J Med Chem. 48: 4586-95. PMID: 15999996
- Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration. | Bourguignon, LY., et al. 2007. J Biol Chem. 282: 19426-41. PMID: 17493932
- Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system. | Lenman, A. and Fowler, CJ. 2007. Br J Pharmacol. 151: 1343-51. PMID: 17592505
- Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils. | Wozniok, I., et al. 2008. Cell Microbiol. 10: 807-20. PMID: 18034864
- HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3. | Gupta, P., et al. 2009. PLoS One. 4: e4363. PMID: 19204783
- Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. | Shen, T., et al. 2010. Biol Pharm Bull. 33: 128-32. PMID: 20045950
- The neurotrophic factor pleiotrophin modulates amphetamine-seeking behaviour and amphetamine-induced neurotoxic effects: evidence from pleiotrophin knockout mice. | Gramage, E., et al. 2010. Addict Biol. 15: 403-12. PMID: 20192945
- Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression. | Bleumink, M., et al. 2011. Cell Death Differ. 18: 362-70. PMID: 20706274
- TGF-β signaling is required for maintenance of retinal ganglion cell differentiation and survival. | Walshe, TE., et al. 2011. Neuroscience. 189: 123-31. PMID: 21664439
- Pseudomonas aeruginosa pyocyanin activates NRF2-ARE-mediated transcriptional response via the ROS-EGFR-PI3K-AKT/MEK-ERK MAP kinase signaling in pulmonary epithelial cells. | Xu, Y., et al. 2013. PLoS One. 8: e72528. PMID: 24015256
- Melanoma upregulates ICAM-1 expression on endothelial cells through engagement of tumor CD44 with endothelial E-selectin and activation of a PKCα-p38-SP-1 pathway. | Zhang, P., et al. 2014. FASEB J. 28: 4591-609. PMID: 25138157
- Polychlorinated biphenyl quinone induces endothelial barrier dysregulation by setting the cross talk between VE-cadherin, focal adhesion, and MAPK signaling. | Zhang, P., et al. 2015. Am J Physiol Heart Circ Physiol. 308: H1205-14. PMID: 25770237
- Tetramethylpyrazine Promotes Migration of Neural Precursor Cells via Activating the Phosphatidylinositol 3-Kinase Pathway. | Kong, X., et al. 2016. Mol Neurobiol. 53: 6526-6539. PMID: 26614511
- Protective effect of CDDO-ethyl amide against high-glucose-induced oxidative injury via the Nrf2/HO-1 pathway. | Zhang, CX., et al. 2017. Spine J. 17: 1017-1025. PMID: 28343048
- MAPK1 of Leishmania donovani interacts and phosphorylates HSP70 and HSP90 subunits of foldosome complex. | Kaur, P., et al. 2017. Sci Rep. 7: 10202. PMID: 28860596
Inhibitor of:
ERK 2, and Ser/Thr Protein Kinase.Activator of:
Skp2 p45.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERK Inhibitor, 5 mg | sc-221593 | 5 mg | $134.00 |