SEP15 Inhibitors
SEP15 inhibitors are a class of chemical compounds that specifically target and modulate the function of the Selenoprotein 15 (SEP15). These inhibitors are designed to interact with SEP15, a crucial component of the selenoprotein synthesis machinery, which plays a pivotal role in the synthesis of selenoproteins. Selenoproteins are a unique class of proteins that contain the amino acid selenocysteine (Sec), which is incorporated into their structure in a highly regulated manner. SEP15 is responsible for ensuring the accurate incorporation of selenocysteine into selenoproteins during their biosynthesis.
SEP15 inhibitors work by interfering with the enzymatic activities associated with SEP15. These compounds typically target the active site of SEP15, where the selenocysteine biosynthesis process takes place. By binding to SEP15, these inhibitors can disrupt its function, ultimately affecting the synthesis of selenoproteins. Understanding the precise mechanisms and effects of SEP15 inhibitors on selenoprotein expression and function remains an active area of research, with potential implications for various fields of biology and biochemistry.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen is an organoselenium compound that can mimic glutathione peroxidase, an enzyme which indirectly reduces the activity of SEP15 by decreasing oxidative stress and restoring redox homeostasis, thereby limiting the substrate availability for SEP15. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin is a gold-containing compound that inhibits thioredoxin reductase, an enzyme that supports the antioxidant function of SEP15. By inhibiting this enzyme, auranofin can decrease SEP15 activity by disrupting the cellular redox balance. | ||||||
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $70.00 $112.00 | 4 | |
Methimazole is a thiourea derivative that can inhibit the synthesis of selenium-containing proteins like SEP15 by interfering with the utilization of selenium. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can chelate metals and has been shown to inhibit various selenoproteins; it may decrease SEP15 activity by altering its metal cofactor environment or through off-target effects on selenoprotein biosynthesis. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $45.00 $115.00 | 2 | |
Clioquinol is a metal chelator that can indirectly affect SEP15 by chelating the trace elements required for its activity, thus potentially decreasing SEP15 function. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $37.00 $56.00 $224.00 $1997.00 | ||
6-Propyl-2-thiouracil, like methimazole, is for hyperthyroidism and can inhibit the utilization of iodine and selenium, possibly reducing SEP15 activity through impaired selenium metabolism. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine can increase reactive oxygen species (ROS) levels within cells and may decrease SEP15 activity by increasing oxidative stress, which can overwhelm the antioxidant capacity of SEP15. | ||||||
Benzyl isothiocyanate | 622-78-6 | sc-204641 sc-204641A | 5 g 25 g | $47.00 $156.00 | 1 | |
Benzyl isothiocyanate can modify cysteine residues in proteins and potentially modulate SEP15 activity by causing conformational changes or affecting its interaction with other proteins. | ||||||
Copper diethyldithiocarbamate | 13681-87-3 | sc-486269 | 25 g | $222.00 | 1 | |
Copper diethyldithiocarbamate is a chelating agent that can sequester metal ions and is a known inhibitor of superoxide dismutase (SOD). By chelating metals, it may indirectly affect SEP15 activity. | ||||||