SCRG1 Activators

SCRG1, also known as Scrapie Responsive Gene 1, is a protein that, in humans, is encoded by the SCRG1 gene. This gene was initially identified in a study investigating genes that were upregulated in the brains of sheep infected with the prion disease scrapie, hence its name.The SCRG1 protein is a secreted growth factor that acts through its receptor, BMPR-IB, a bone morphogenetic protein receptor. Together, they play a role in promoting the survival and growth of neural cells.it is known to be expressed in various tissues, including the heart, brain, and skeletal muscle. Its expression in the brain is particularly high during embryonic development, suggesting it may play a role in neural development. Moreover, it has been shown to stimulate neurite outgrowth, further supporting its role in nervous system development.

SCRG1 also plays a role in the regeneration of peripheral nerves. Studies have shown that SCRG1 can promote the growth of Schwann cells, which are essential for nerve regeneration, and can stimulate axonal sprouting.Understanding the functions of SCRG1 could provide valuable insights into the molecular mechanisms underlying neural development, regeneration, and potentially prion diseases.