Scratch1 Inhibitors
Chemical inhibitors of Scratch1 can act through various pathways to achieve functional inhibition. Cyclopamine and Jervine target the Hedgehog (Hh) signaling pathway, which is essential for the regulation of gene transcription during neuronal differentiation, a process where Scratch1 plays an important role. These inhibitors bind to the Smoothened (SMO) receptor, reducing Hh pathway signaling and thus inhibiting Scratch1-dependent transcriptional activity. GANT61, by directly targeting GLI transcription factors-the terminal effectors of the Hedgehog pathway-suppresses the induction of target gene expression, thereby inhibiting Scratch1. Similarly, Robotnikinin binds to Sonic Hedgehog (Shh), blocking its interaction with PTCH1 and consequently disrupting the downstream signaling that activates Scratch1.
On another front, inhibitors like Curcumin, PKF118-310, IWP-2, XAV-939, LGK-974, and PNU-74654 interfere with the Wnt signaling pathway, which has been implicated in regulating processes that involve Scratch1. Curcumin inhibits β-catenin's transcriptional activity, which is a component of Wnt signaling likely involved in the regulation of Scratch1. PKF118-310 acts as a β-catenin/Tcf-4 antagonist, suppressing the transcriptional activity of Scratch1. IWP-2 inhibits Wnt production by blocking Porcupine, leading to reduced Wnt signaling and subsequent decrease in Scratch1 activity. XAV-939 and LGK-974 similarly inhibit Wnt signaling through the stabilization of Axin and prevention of Wnt ligand secretion, respectively, leading to decreased Scratch1 activity. PNU-74654 disrupts the interaction between β-catenin and TCF, while FH535, a dual inhibitor, not only affects β-catenin/Tcf signaling but also peroxisome proliferator-activated receptor (PPAR) signaling, collectively leading to a decrease in the transcriptional activity of Scratch1, effectively inhibiting its function.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine inhibits the Hedgehog (Hh) signaling pathway by binding to and interfering with the Smoothened (SMO) receptor. Scratch1 is involved in the regulation of gene transcription during neuronal differentiation and is downstream of the Hh pathway. Inhibition of SMO by Cyclopamine can decrease the Hh pathway signaling, thereby inhibiting the transcriptional activity of Scratch1. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $64.00 $131.00 $204.00 | 6 | |
GANT61 directly targets GLI transcription factors, which are the terminal effectors of the Hedgehog pathway, inhibiting their ability to induce target gene expression. Scratch1, being a transcription factor regulated by Hedgehog signaling, is inhibited by the suppression of GLI-mediated transcriptional activation. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
Jervine acts similarly to Cyclopamine by antagonizing the Smoothened receptor, which is crucial for the Hedgehog signaling pathway. The inhibition of this pathway prevents the activation of Scratch1-dependent transcriptional processes. | ||||||
Robotnikinin | 1132653-79-2 | sc-396554 | 1 mg | $650.00 | 1 | |
Robotnikinin disrupts Hedgehog signaling by binding to Sonic Hedgehog (Shh), inhibiting its interaction with PTCH1, the receptor that normally inhibits Smoothened. This inhibition can disrupt the downstream signaling required for Scratch1 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit the transcriptional activity of β-catenin, which is involved in the Wnt signaling pathway. As Scratch1 is implicated in the progression of neural differentiation and is potentially regulated by Wnt signaling, curcumin inhibition of β-catenin can result in the suppression of Scratch1 activity. | ||||||
PKF118-310 | 84-82-2 | sc-364590 sc-364590A | 5 mg 25 mg | $180.00 $651.00 | ||
PKF118-310 is a β-catenin/Tcf-4 antagonist that inhibits Wnt signaling. By blocking this pathway, PKF118-310 can suppress the transcriptional activity of downstream targets like Scratch1, which may be influenced by Wnt signaling outputs. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
IWP-2 inhibits Wnt production by blocking Porcupine, an O-acyltransferase required for Wnt ligand secretion. Reduced Wnt signaling can lead to decreased activation of Scratch1-related transcriptional programs. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV-939 stabilizes Axin by inhibiting tankyrase, leading to the degradation of β-catenin, a key mediator in the Wnt pathway. As Scratch1 function is potentially regulated through Wnt signaling, the inhibition of β-catenin by XAV-939 can result in decreased Scratch1 activity. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $359.00 $1295.00 | 2 | |
LGK-974 is a Porcupine inhibitor that prevents Wnt ligand palmitoylation and secretion, thereby inhibiting Wnt signaling. This reduction in Wnt activity can lead to a decrease in Scratch1 transcriptional activity, as it is part of the pathway influenced by Wnt. | ||||||
PNU-74654 | 113906-27-7 | sc-258020 sc-258020A | 5 mg 25 mg | $131.00 $495.00 | 7 | |
PNU-74654 acts as an antagonist of the Wnt/β-catenin signaling pathway by disrupting the interaction between β-catenin and TCF. The inhibition of this signaling pathway can decrease the transcriptional activity of Scratch1, which may be regulated by Wnt/β-catenin signaling. | ||||||