SCML1 Activators
SCML1 Activators largely function through their influence on chromatin remodeling processes. SCML1 serves as a part of the Polycomb group (PcG) complex, which is directly involved in transcriptional repression through chromatin remodeling. This complex exerts its function by modifying the chromatin structure, and any changes in the chromatin state can directly influence the activity of SCML1. For instance, Trichostatin A, Suberanilohydroxamic acid (SAHA), Scriptaid, Oxamflatin,MS-275, MC1568, and Sodium butyrate, all histone deacetylase inhibitors, promote acetylation of histones, leading to a relaxed chromatin state that can enhance the functional activity of SCML1. In a similar vein, BIX-01294, a G9a histone methyltransferase inhibitor, can lead to a decrease in histone methylation, promoting chromatin remodeling and consequently enhancing the functional activity of SCML1.
A second group of SCML1 activators, including 5-Azacytidine, 5-Aza-2'-deoxycytidine, and RG108, are DNA methyltransferase inhibitors. These compounds cause DNA demethylation, another form of chromatin remodeling, which can enhance the functional activity of SCML1. Mithramycin A, a DNA-binding antibiotic, is another SCML1 activator. By interfering with transcription factor binding to the DNA, it alters gene expression and can indirectly activate SCML1.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a potent inhibitor of histone deacetylases, which can cause the acetylation of histones and non-histone proteins, resulting in chromatin remodeling. SCML1, as a part of the Polycomb group (PcG) complex, is involved in transcriptional repression through chromatin remodeling. Therefore, Trichostatin A can indirectly enhance the functional activity of SCML1 by promoting the remodeling of chromatin structure. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is another histone deacetylase inhibitor, which leads to the acetylation of histones and the subsequent remodeling of chromatin. This can enhance the functional activity of SCML1, which is part of the PcG complex involved in transcriptional repression through chromatin remodeling. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can lead to DNA demethylation and chromatin remodeling. This can enhance the functional activity of SCML1, as SCML1 is part of the PcG complex involved in the transcriptional repression through chromatin remodeling. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2'-deoxycytidine is also a DNA methyltransferase inhibitor that causes DNA demethylation and chromatin remodeling. This can enhance the functional activity of SCML1, which is part of the PcG complex involved in transcriptional repression through chromatin remodeling. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A is a DNA-binding antibiotic that interferes with the binding of transcription factors to the DNA, leading to altered gene expression. This could indirectly activate SCML1, as it is part of the PcG complex involved in transcriptional repression. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $63.00 $179.00 | 11 | |
Scriptaid is a histone deacetylase inhibitor, leading to increased acetylation of histones and subsequent chromatin remodeling. This can enhance the functional activity of SCML1, which is part of the PcG complex involved in transcriptional repression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor that can cause DNA demethylation and chromatin remodeling. This can enhance the functional activity of SCML1, which is part of the PcG complex involved in transcriptional repression. | ||||||
PKR Inhibitor | 608512-97-6 | sc-204200C sc-204200 sc-204200D sc-204200E sc-204200A sc-204200B | 1 mg 5 mg 10 mg 25 mg 50 mg 100 mg | $64.00 $150.00 $300.00 $600.00 $800.00 $1800.00 | 5 | |
Oxamflatin is a histone deacetylase inhibitor that can lead to the acetylation of histones and the subsequent remodeling of chromatin. This can enhance the functional activity of SCML1, which is part of the PcG complex involved in transcriptional repression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 is a histone deacetylase inhibitor. It can lead to the acetylation of histones and the subsequent remodeling of chromatin, which can enhance the functional activity of SCML1, a part of the PcG complex. | ||||||
MC 1568 | 852475-26-4 | sc-362767 sc-362767A | 10 mg 50 mg | $179.00 $566.00 | 4 | |
MC1568 is a histone deacetylase inhibitor that can lead to increased acetylation of histones and subsequent chromatin remodeling. This can enhance the functional activity of SCML1, which is part of the PcG complex involved in transcriptional repression. | ||||||