SAHH Activators

SAHH activators constitute a group of compounds that directly or indirectly modulate SAHH expression and function. Betaine activates SAHH by promoting cellular methylation, donating a methyl group to homocysteine and facilitating SAM synthesis. Methionine, as a precursor for SAM, activates SAHH by providing a substrate for SAM synthesis. Choline contributes to SAM synthesis, serving as a methyl donor and activating SAHH. Adenosine activates SAHH through SAM regeneration, participating in the recycling of SAM and sustaining SAHH enzymatic activity. Lysine activates SAHH by contributing to SAM synthesis, providing a methyl donor for SAHH.

Pyridoxal-5'-phosphate (PLP) activates SAHH through modulation of one-carbon metabolism, serving as a cofactor in this pathway. Nicotinamide riboside activates SAHH through NAD+ synthesis, influencing SAM levels and promoting SAHH activation. Folic acid (Vitamin B9) activates SAHH by contributing to one-carbon metabolism, essential for SAM synthesis. Glycine and serine activate SAHH through modulation of one-carbon metabolism, participating in SAM synthesis and promoting SAHH activation. Vitamin B6 (Pyridoxine) and Vitamin B12 (Cobalamin) activate SAHH by influencing one-carbon metabolism, essential for SAM synthesis and promoting SAHH activation. These activators offer valuable tools for investigating the intricate regulatory networks influencing SAHH, providing insights into its roles in cellular processes and signaling pathways.