S3-12 Activators are a distinctive class of chemical compounds known for their role in enhancing the biological activity of S3-12, a protein that plays a pivotal role in certain cellular pathways. These activators work by engaging with and influencing the signaling mechanisms that S3-12 is directly involved in, thereby amplifying its functional activity within cells. One of the primary actions of these activators is to modulate intracellular processes to create an environment conducive to the protein's activation. For example, specific S3-12 Activators may increase the levels of secondary messengers within the cell, which are crucial for the protein's activity. This could include the elevation of cyclic adenosine monophosphate (cAMP) levels, which in turn can activate protein kinase A (PKA). PKA then phosphorylates various substrates that directly interact with S3-12, leading to its enhanced functional state. Furthermore, certain S3-12 Activators might influence the redox state of the cell, which can affect the thiol groups of proteins, thus altering the activity of S3-12 through conformational changes or by affecting its interaction with other cellular components.
In addition to affecting secondary messengers, S3-12 Activators may also exert their influence by altering lipid signaling pathways. These compounds can modify the production or degradation of key signaling lipids, thus influencing the localization and activity of S3-12 within the lipid microdomains of the cell membrane. Another subset of S3-12 Activators might bind directly to the regulatory domains of the protein, thereby inducing a structural change that results in its activation. These activators are often highly specific to S3-12, ensuring that their effects are limited to the intended pathways without undesired cross-reactivity. The specificity and precision of S3-12 Activators make them valuable tools for probing the intricate biological functions of S3-12 and for elucidating its role within cellular signaling networks. By directly or indirectly promoting the activity of S3-12, these activators facilitate a deeper understanding of the protein's contribution to the dynamic processes that sustain cellular homeostasis and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various substrates, possibly enhancing the functional activity of S3-12 if it is cAMP-responsive. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC). Activated PKC phosphorylates target proteins, which may result in increased S3-12 activity if S3-12 is regulated by PKC-mediated phosphorylation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, potentially activating calcium-dependent protein kinases, and could thereby augment S3-12 activity if it is calcium-responsive. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels. This elevation could enhance S3-12 activity if it is modulated by these cyclic nucleotides. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can lead to alterations in the PI3K/Akt pathway. If S3-12 activity is modulated by this pathway, its inhibition could result in compensatory mechanisms that enhance S3-12 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which may lead to changes in the MAPK pathway. If S3-12 functions downstream of or is regulated by the MAPK pathway, this could result in an upregulation of S3-12 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore, which, similar to Ionomycin, increases intracellular calcium and could enhance S3-12 activity if it is calcium-dependent. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins. This could enhance the activity of S3-12 if it is positively regulated by phosphorylation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor with a broad range of targets. It could potentially increase S3-12 activity by inhibiting kinases that negatively regulate S3-12. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that activates sphingosine-1-phosphate receptors, potentially influencing intracellular signaling pathways that could enhance S3-12 activity if S3-12 is part of those pathways. | ||||||