RT1-B Activators
RT1-B Activators primarily function through immunosuppression or anti-inflammatory mechanisms. Some of these activators, such as Cyclosporine, Rapamycin, and FK506, exert their effects by inhibiting key immunological pathways. Cyclosporine and FK506 inhibit calcineurin, thus reducing IL-2 transcription and T-cell activation, which allows for an increase in the functional activity of RT1-B. Rapamycin, on the other hand, inhibits the mTOR pathway, causing a reduction in T-cell proliferation and B-cell differentiation, which indirectly enhances the function of RT1-B by reducing competition for antigen presentation.
Other RT1-B activators, like Aspirin, Indomethacin, Sulindac, Meloxicam, Celecoxib, Rofecoxib, Etoricoxib, and Parecoxib, are non-steroidal anti-inflammatory drugs (NSAIDs) or selective COX-2 inhibitors. These compounds inhibit the COX enzymes, reducing the production of pro-inflammatory prostaglandins and thromboxanes. This decreases inflammation and can indirectly increase the functional activity of RT1-B. Dexamethasone, a glucocorticoid receptor agonist, also falls into this category. By reducing the production of pro-inflammatory cytokines, these agents can indirectly enhance the functional activity of RT1-B by decreasing inflammation and the immune response.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporine is an immunosuppressive drug that binds to the cytosolic protein cyclophilin (immunophilin) in lymphocytes. This complex inhibits calcineurin which is normally responsible for activating the transcription of IL-2. The reduction in IL-2 leads to a decreased function of effector T-cells and thus, reduces the immune response allowing for an increase in the functional activity of RT1-B. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin (Sirolimus) is an immunosuppressant drug that binds to FKBP12 to form a complex that inhibits the mTOR pathway. This inhibition leads to a reduction in T-cell proliferation and B-cell differentiation, indirectly enhancing the function of RT1-B by reducing competition for antigen presentation. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 (Tacrolimus) binds to FKBP12 to inhibit calcineurin, similar to cyclosporine. The FK506-FKBP12 complex inhibits the dephosphorylation of NFAT, which reduces the transcription of IL-2, leading to decreased T-cell activation which indirectly enhances RT1-B function. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid receptor agonist that reduces the production of proinflammatory cytokines. This reduction can indirectly enhance the functional activity of RT1-B by reducing the immune response. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin inhibits cyclooxygenase (COX) enzymes, leading to a decrease in the production of prostaglandins and thromboxanes. This can potentially reduce inflammation and thus indirectly enhance RT1-B function. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX enzymes similar to Aspirin, therefore reducing inflammation and indirectly enhancing RT1-B function. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $32.00 $86.00 $150.00 | 3 | |
Sulindac is another NSAID that inhibits COX enzymes, reducing inflammation and thus can indirectly increase the functional activity of RT1-B. | ||||||
Meloxicam | 71125-38-7 | sc-200626 sc-200626A sc-200626B | 20 mg 100 mg 500 mg | $36.00 $94.00 $156.00 | 3 | |
Meloxicam is a selective COX-2 inhibitor that reduces the production of pro-inflammatory prostaglandins, potentially leading to an indirect enhancement of RT1-B function. | ||||||
Vioxx | 162011-90-7 | sc-208486 | 100 mg | $190.00 | 3 | |
Rofecoxib is a selective COX-2 inhibitor similar to Celecoxib and Meloxicam, that can reduce inflammation and indirectly enhance RT1-B function. | ||||||
Etoricoxib | 202409-33-4 | sc-218446 | 10 mg | $36.00 | 3 | |
Etoricoxib is another selective COX-2 inhibitor that can reduce inflammation and indirectly enhance RT1-B function. | ||||||