RREB1 Inhibitors

RREB1 inhibitors belong to a distinctive chemical class that specifically targets the Repressor Element 1-Silencing Transcription Factor (REST) corepressor 1 (CoREST) Binding protein 1 (RREB1). RREB1, also known as Ras Responsive Element Binding Protein 1, is a transcription factor that plays a crucial role in regulating gene expression. It is involved in various cellular processes, including cell proliferation, differentiation, and survival. The inhibitors designed for RREB1 act by modulating its activity, either by impeding its binding to specific DNA sequences or by disrupting its interaction with other cellular components.

RREB1 inhibitors exhibit a diverse array of chemical scaffolds, reflecting the multifaceted nature of their binding interactions with the target protein. Researchers have explored small molecules as well as biologics as potential RREB1 inhibitors, each with unique mechanisms of action. The development of these inhibitors has been driven by the need to better understand the regulatory networks controlled by RREB1 and to explore potential applications in various biological contexts. Furthermore, ongoing studies aim to elucidate the structural determinants governing the specificity of RREB1 inhibitors, paving the way for the rational design of novel compounds with enhanced potency and selectivity.