RPA40 Inhibitors
RPA40 inhibitors belong to a distinct chemical class that has garnered significant attention in the field of molecular biology and drug discovery. The acronym RPA stands for Replication Protein A, a crucial component in DNA replication and repair processes. RPA40, a subunit of the Replication Protein A complex, plays a pivotal role in maintaining genomic stability by participating in DNA single-strand break repair and mediating the cellular response to DNA damage. Inhibitors targeting RPA40 are designed to modulate the function of this specific subunit, disrupting the intricate network of cellular mechanisms that rely on its activity.
RPA40 inhibitors is meticulously crafted to interfere with the binding sites or enzymatic functions associated with RPA40. By impeding the normal functioning of RPA40, these inhibitors aim to perturb the intricate dance of cellular machinery involved in DNA replication and repair. This disruption may lead to a cascade of molecular events, potentially affecting cell cycle progression and inducing genomic instability. Researchers are keenly interested in elucidating the specific molecular interactions between RPA40 inhibitors and their target, as this knowledge is essential for optimizing drug design and understanding the potential implications for cellular processes. The development of RPA40 inhibitors represents a promising avenue for advancing our understanding of DNA maintenance mechanisms and could have far-reaching implications for various fields, including cancer research and molecular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that prevents the re-ligation step of the DNA cleavage reaction, which leads to the accumulation of single-strand DNA breaks. This can disrupt the function of the RPA complex, including RPA40, as it is essential for single-strand DNA binding during replication and repair. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that prevents the religation of the DNA strands and causes DNA breaks. The RPA complex, including RPA40, is required for the repair of these breaks, hence etoposide can indirectly affect its function. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms intrastrand and interstrand DNA crosslinks that hinder DNA replication and transcription. The RPA complex is involved in the recognition and repair of these lesions, thus cisplatin can indirectly impact the function of RPA40. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide inhibits the ATPase activity of XPB, a subunit of the transcription factor TFIIH. This can affect the nucleotide excision repair pathway where the RPA complex is involved, potentially impacting RPA40. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, causing a reduction in the dNTP pool and stalling DNA replication. This can indirectly affect the RPA complex and its subunit RPA40. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib is a PARP inhibitor that impairs the repair of single-strand DNA breaks, leading to the formation of double-strand breaks. The RPA complex is involved in the repair of these breaks, hence olaparib can indirectly affect the function of RPA40. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin inhibits DNA polymerase α and δ, leading to replication fork stalling and potentially affecting the RPA complex and its subunit RPA40. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, leading to a reduction in the guanine nucleotide pool and potentially affecting DNA replication where the RPA complex is involved. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil is incorporated into RNA and DNA in place of uracil and thymine, causing DNA damage. The RPA complex is involved in the recognition and repair of these lesions, thus 5-fluorouracil can indirectly impact the function of RPA40. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
2'-Deoxy-2',2'-difluorocytidine is incorporated into DNA, leading to chain termination. This can affect the function of the RPA complex, including RPA40. | ||||||