RNA pol β Inhibitors

RNA pol β inhibitors, as conceptualized here, comprise a range of chemical compounds that indirectly impact the function of a RNA polymerase subunit, RNA pol β. These inhibitors utilize various mechanisms to impede the function of RNA polymerases, potentially affecting the β subunit. Compounds like Actinomycin D and α-Amanitin target RNA synthesis directly. Actinomycin D binds to DNA and inhibits RNA synthesis by RNA polymerases, which could affect the function of the β subunit. α-Amanitin, on the other hand, binds to the core enzyme of RNA polymerase II, which may include a β-like subunit.

Other inhibitors, such as Rifampicin and Streptolydigin, target bacterial RNA polymerase, which has a beta subunit integral to its function. By binding to and inhibiting this enzyme, these compounds can potentially influence processes that are similar in eukaryotic RNA polymerases. Additional compounds, like Cordycepin and DRB, inhibit RNA synthesis by terminating elongation or inhibiting elongation, respectively, actions that could indirectly impact the function of a β-like subunit in RNA polymerases. Sorangicin A and CBR703 also target bacterial RNA polymerase, suggesting their potential effect on similar subunits in other RNA polymerases.