RIMBP3B Activators

RIMS Binding Protein 3B (RIM-BP3B) is a member of the RIM-binding protein family, which is known to be involved in synaptic vesicle exocytosis. RIM-BP proteins are characterized by their ability to bind to RIM proteins, which are central organizers of the presynaptic active zone. RIM-BP3B, like other proteins in this family, is thought to play a role in bridging RIM proteins with other components of the synaptic release machinery, thereby facilitating neurotransmitter release.

The RIM-BP family is typically responsible for modulating synaptic transmission by influencing the assembly and stabilization of the synaptic vesicle release complex. RIM-BP3B is likely to contribute to this process by interacting through its multiple domains, including Src homology 3 (SH3) domains that mediate protein-protein interactions relevant to synaptic function. These interactions are essential for the precise alignment of synaptic vesicles at the active zone, enabling efficient and rapid neurotransmitter release in response to action potentials.The precise expression patterns and specific functions of RIM-BP3B may differ slightly from other members of the RIM-BP family, potentially providing unique contributions to synapse specificity and plasticity. Its role may extend to the regulation of synaptic strength and the maintenance of synaptic architecture, particularly in the central nervous system.