RIMBP3B Activators
RIMS Binding Protein 3B (RIM-BP3B) is a member of the RIM-binding protein family, which is known to be involved in synaptic vesicle exocytosis. RIM-BP proteins are characterized by their ability to bind to RIM proteins, which are central organizers of the presynaptic active zone. RIM-BP3B, like other proteins in this family, is thought to play a role in bridging RIM proteins with other components of the synaptic release machinery, thereby facilitating neurotransmitter release.
The RIM-BP family is typically responsible for modulating synaptic transmission by influencing the assembly and stabilization of the synaptic vesicle release complex. RIM-BP3B is likely to contribute to this process by interacting through its multiple domains, including Src homology 3 (SH3) domains that mediate protein-protein interactions relevant to synaptic function. These interactions are essential for the precise alignment of synaptic vesicles at the active zone, enabling efficient and rapid neurotransmitter release in response to action potentials.The precise expression patterns and specific functions of RIM-BP3B may differ slightly from other members of the RIM-BP family, potentially providing unique contributions to synapse specificity and plasticity. Its role may extend to the regulation of synaptic strength and the maintenance of synaptic architecture, particularly in the central nervous system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels which may enhance RIMS binding protein 3B expression via PKA activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits PDE4, increasing cAMP concentrations, potentially upregulating RIMS binding protein 3B through cAMP response elements. | ||||||
BAY 60-6583 | 910487-58-0 | sc-503262 | 10 mg | $210.00 | ||
BAY 60-7550 inhibits PDE2, raising cAMP levels, which could lead to enhanced RIMS binding protein 3B expression by PKA-mediated signaling. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H-89 is a PKA inhibitor that may indirectly upregulate RIMS binding protein 3B through feedback mechanisms that compensate for reduced PKA activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that raises cAMP levels, potentially promoting RIMS binding protein 3B expression through cAMP-mediated pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective PDE inhibitor which increases cAMP, possibly leading to the upregulation of RIMS binding protein 3B via cAMP-PKA signaling. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Br-cAMP is a cAMP analog that activates PKA, which might induce the expression of RIMS binding protein 3B through downstream effects on gene transcription. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that may enhance RIMS binding protein 3B expression by mimicking cAMP and activating PKA. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates the MAPK pathway, potentially resulting in the increased expression of RIMS binding protein 3B through MAPK-mediated transcriptional regulation. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a CaMKII inhibitor, which could lead to upregulated RIMS binding protein 3B expression as a homeostatic response to altered calcium signaling. | ||||||