Rieske FeS Activators

Rieske FeS Inhibitors encompass a range of compounds that indirectly affect the functionality of the Rieske Iron-Sulfur Protein by targeting various components of the electron transport chain or by directly interfering with the integrity of iron-sulfur clusters. The inhibitors listed above are not specific antagonists of Rieske FeS but function by disrupting the electron flow or the structural components of the complexes in which Rieske FeS operates.

The primary mechanism by which these inhibitors function involves the obstruction of electron transfer in the electron transport chain. Compounds like Antimycin A, Myxothiazol, and Stigmatellin specifically target the cytochrome bc1 complex, thereby indirectly impacting the activity of the Rieske FeS protein. Other inhibitors such as Rotenone and Sodium Azide affect different complexes within the electron transport chain, indirectly influencing the overall electron flow and, consequently, the function of Rieske FeS. Additionally, compounds that chelate metal ions or disrupt iron-sulfur clusters, such as Thenoyltrifluoroacetone, Zinc, and Cadmium, can potentially alter the structural and functional integrity of the Rieske FeS protein. Nitric Oxide and Carbon Monoxide are known to modify iron-containing proteins, further illustrating the diverse mechanisms through which these inhibitors can indirectly impact Rieske FeS activity.