Ribosomal Protein L6 Activators
Ribosomal Protein L6 activators encompass a group of chemical entities that target and modulate the activity of Ribosomal Protein L6 (RPL6), which is an integral component of the 60S large ribosomal subunit in eukaryotic cells. RPL6 is involved in protein synthesis, playing a role in the assembly and stability of the ribosome, and in the interaction with ribosomal RNA and other ribosomal proteins during translation.
Direct activators of RPL6 bind to the protein and alter its conformation in a way that enhances its function in the ribosome. These activators might increase the affinity of RPL6 for rRNA or facilitate the proper folding and assembly of the ribosomal subunits. This could lead to a more efficient ribosome, capable of synthesizing proteins at an increased rate or with greater fidelity. The mechanism of action may involve stabilizing the RPL6 in such a way that it promotes the optimal interaction between ribosomal components necessary for the translation process. Indirect activators of RPL6 may not interact with the protein directly but could affect its activity by modulating the cellular machinery that controls ribosome assembly and function. These chemicals could influence the expression levels of RPL6 by affecting gene transcription or mRNA stability, thereby increasing the availability of RPL6 for ribosome assembly. Alternatively, they might inhibit the degradation pathways of RPL6, thus prolonging the protein's lifespan within the cell. Additionally, post-translational modifications of RPL6, such as phosphorylation, acetylation, or methylation, could be targets of indirect activators, thereby altering the activity and interactions of RPL6 within the ribosome.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D inhibits RNA polymerase, which can lead to a decrease in protein synthesis. This could indirectly stimulate Ribosomal Protein L6 (RPL6) as a compensatory mechanism to maintain protein synthesis. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide binds to the 60S subunit of the ribosome and inhibits protein synthesis. This can stimulate RPL6 as part of a compensatory response to maintain protein synthesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a kinase that controls cell growth and proliferation. When mTOR is inhibited, the cells may increase the production of ribosomal proteins like RPL6 to maintain protein synthesis. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B inhibits nuclear export by binding to CRM1. By doing so, it can accumulate ribosomal proteins, including RPL6, in the nucleus, indirectly increasing its activity. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $40.00 $210.00 $816.00 $65.00 | 394 | |
Puromycin mimics an aminoacyl-tRNA, causing premature chain termination during translation. This can indirectly activate RPL6 as part of a compensatory mechanism to maintain protein synthesis. | ||||||
Azithromycin | 83905-01-5 | sc-254949 sc-254949A sc-254949B sc-254949C sc-254949D | 25 mg 50 mg 500 mg 1 g 5 g | $51.00 $101.00 $255.00 $357.00 $714.00 | 17 | |
Azithromycin binds to the 50S subunit of the ribosome and inhibits protein synthesis. This can stimulate RPL6 as part of a compensatory response to maintain protein synthesis. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $51.00 $123.00 $178.00 | 11 | |
Homoharringtonine binds to the A-site cleft of the ribosome, inhibiting protein synthesis. This can indirectly stimulate RPL6 as a compensatory mechanism to maintain protein synthesis. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin inhibits protein synthesis by binding to the 60S subunit of the ribosome. This can stimulate RPL6 as part of a compensatory response to maintain protein synthesis. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $352.00 $566.00 $1331.00 $2453.00 | ||
Emetine inhibits protein synthesis by binding to the 40S subunit of the ribosome. This can indirectly stimulate RPL6 as part of a compensatory mechanism to maintain protein synthesis. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Chloramphenicol inhibits protein synthesis by binding to the 50S subunit of the ribosome. This can stimulate RPL6 as part of a compensatory response to maintain protein synthesis. | ||||||