Ribosomal Protein L14 Activators
CAB39L Activators are a class of chemical compounds that enhance the functional activity of CAB39L through indirect mechanisms involving the activation of the AMPK pathway or related upstream regulators. Forskolin, by increasing intracellular cAMP levels, leads to the activation of PKA, which can phosphorylate proteins that regulate the AMPK pathway, of which CAB39L is a critical component. Metformin, Phenformin, Berberine, and Salicylate, as AMPK activators, enhance the activity of CAB39L by increasing the demand for its scaffolding function in the activation process of AMPK. The role of CAB39L in stabilizing the active conformation of AMPK is crucial, and therefore any compound that can activate AMPK, like AICAR and A769662, serves to enhance CAB39L activity.
Resveratrol activates SIRT1, which in turn deacetylates and activates LKB1, a kinase upstream of AMPK. This activation cascade results in the activation of AMPK and an indirect increase in CAB39L functionality due to its association with the AMPK complex. Similarly, D4476 as a CK1 inhibitor, and C2 Ceramide as an activator of PP2A, modulate the activity of LKB1, which is an essential kinase for AMPK activation. Through these actions, they promote the activation of CAB39L. PT1 acts as an allosteric activator of AMPK, enhancing the activity ofCAB39L through its role in the LKB1-AMPK complex. Lastly, Quercetin, through its ability to activate AMPK, supports the functional activity of CAB39L by necessitating its stabilizing presence within the active AMPK complex.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylyl cyclase, increasing cAMP levels within cells. Elevated cAMP activates PKA, which can phosphorylate and thereby activate proteins that regulate the CAB39L-associated AMPK pathway, ultimately leading to the activation of CAB39L. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMP analog that activates AMPK. Through the activation of AMPK, CAB39L activity is enhanced since CAB39L is a known binding partner that stabilizes the active conformation of AMPK. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin activates AMPK, which is part of the signaling pathway involving CAB39L. Through the activation of AMPK, Metformin indirectly enhances the activity of CAB39L, as it is necessary for AMPK's full activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a SIRT1 activator, which can deacetylate and activate LKB1, leading to the activation of AMPK and subsequently enhancing the activity of CAB39L by promoting its association with AMPK. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662 directly activates AMPK. Since CAB39L functions as a scaffold for the LKB1-AMPK complex, the activation of AMPK by A769662 enhances the activity of CAB39L by stabilizing this complex. | ||||||
Phenformin Hydrochloride | 834-28-6 | sc-219590 | 10 g | $119.00 | 4 | |
Phenformin is another AMPK activator. By activating AMPK, it indirectly enhances CAB39L activity, due to the scaffolding role of CAB39L in the AMPK signaling pathway. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylate activates AMPK. The resulting increase in AMPK activity indirectly enhances the activity of CAB39L, which facilitates the activation of AMPK through complex formation. | ||||||
Casein Kinase I Inhibitor, D4476 | 301836-43-1 | sc-202522 | 1 mg | $99.00 | 6 | |
D4476 is a casein kinase 1 (CK1) inhibitor. CK1 negatively regulates AMPK, thus inhibiting CK1 leads to the activation of AMPK and subsequently an increase in CAB39L activity due to its role in the AMPK pathway. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates AMPK. Enhanced AMPK activity indirectly increases CAB39L activity, as CAB39L is an essential component of the AMPK activation process. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
C2 Ceramide activates protein phosphatase 2A (PP2A), which can dephosphorylate and activate LKB1, leading to AMPK activation and subsequent enhancement of CAB39L activity. | ||||||