RFX5 Inhibitors
RFX5 inhibitors belong to a distinctive chemical class characterized by their ability to selectively modulate the activity of the Regulatory Factor X 5 (RFX5) protein. RFX5 is a pivotal component of the RFX complex, which plays a crucial role in regulating gene expression through its involvement in major histocompatibility complex (MHC) class II transcription. This transcriptional regulation is integral for the adaptive immune response, as MHC class II molecules are essential for presenting antigens to CD4+ T cells. RFX5, as a part of the RFX complex, acts as a transcription factor that binds to the X box motif within the promoter region of MHC class II genes, facilitating their expression.
RFX5 inhibitors represents a significant stride in molecular pharmacology, offering a means to finely modulate immune responses at the genetic level. These inhibitors are designed to interact specifically with the RFX5 protein, impeding its function and subsequently influencing the expression of MHC class II genes. The targeted inhibition of RFX5 holds promise for a range of applications where precise control over the immune system is desired. The chemical class of RFX5 inhibitors underscores the intricate interplay between molecular components in cellular processes and opens avenues for exploring novel strategies in immunomodulation
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a small molecule that inhibits BET bromodomain proteins, which may alter chromatin structure and impact RFX5 transcription. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can prevent the degradation of regulatory proteins that may interact with RFX5. | ||||||
GSK 525762A | 1260907-17-2 | sc-490339 sc-490339A sc-490339B sc-490339C sc-490339D | 5 mg 10 mg 50 mg 100 mg 1 g | $300.00 $540.00 $940.00 $1680.00 $5900.00 | ||
I-BET762 is another BET bromodomain inhibitor which can modulate transcription and potentially affect RFX5 expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is an autophagy inhibitor that can impact cellular degradation pathways, potentially influencing RFX5 stability. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol that can affect multiple signaling pathways and might alter the cellular environment of RFX5. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate various signaling pathways and transcription factors, possibly affecting RFX5-related pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in many cellular processes, potentially altering RFX5-related signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, potentially affecting pathways that regulate RFX5 function or expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, which may influence signaling pathways related to RFX5 activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, which may affect transcription factors and signaling pathways interacting with RFX5. | ||||||