Renal Cell Carcinoma Inhibitors are a chemical class composed of molecules that interact with specific cellular processes. These compounds are often defined by their ability to bind selectively to proteins or enzymes that are crucial in the regulation of cell growth, division, and survival. The intricate design of these inhibitors is informed by a deep understanding of the molecular and genetic mechanisms that drive normal cellular function. Certain pathways, such as those involving the regulation of angiogenesis, the maintenance of cellular metabolism, and the signaling that orchestrates cell proliferation, are key targets for these inhibitors. By focusing on these pathways and the proteins that act as their linchpins, such as tyrosine kinases and various receptors, these compounds can modulate the complex biological interactions within cells.
The development of compounds within this class requires a nuanced approach, as it involves crafting molecules that can achieve high specificity and strong binding affinity for their targets. The inhibitors aimed at pathways responsible for the formation of new cellular networks, for example, must be able to interact with the receptors and signaling molecules that control these processes. Other inhibitors within this class focus on key regulatory proteins that manage cellular metabolism and growth, providing insight into the regulation of these fundamental biological functions. The diversity within this group of compounds is a reflection of the intricate nature of cellular signaling pathways and the proteins that govern them. These molecules vary widely in their structure, the nature of their interaction with target proteins, and the downstream effects they have on cellular processes, which all contribute to a growing understanding of cellular regulation and function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $150.00 $920.00 | 5 | |
Sunitinib is a small molecule multi-kinase inhibitor that targets several receptor tyrosine kinases, including VEGFR, PDGFR, c-Kit, and others. | ||||||
Pazopanib | 444731-52-6 | sc-396318 sc-396318A | 25 mg 50 mg | $127.00 $178.00 | 2 | |
Pazopanib is another small molecule multi-kinase inhibitor that targets VEGFR, PDGFR, c-Kit, and others. | ||||||
XL-184 free base | 849217-68-1 | sc-364657 sc-364657A | 5 mg 10 mg | $92.00 $204.00 | 1 | |
Cabozantinib is a small molecule inhibitor of MET, VEGFR-2, and AXL receptors. | ||||||
Lenvatinib | 417716-92-8 | sc-488530 sc-488530A sc-488530B | 5 mg 25 mg 100 mg | $178.00 $648.00 $1657.00 | 3 | |
Lenvatinib is a small molecule multi-kinase inhibitor that targets VEGFR, FGFR, and PDGFR. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a small molecule multi-kinase inhibitor targeting VEGFR, PDGFR, RAF kinases, and others. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $128.00 $638.00 | 7 | |
Everolimus is a small molecule inhibitor of mTOR (mammalian target of rapamycin) signaling pathway. | ||||||
Regorafenib | 755037-03-7 | sc-477163 sc-477163A | 25 mg 50 mg | $320.00 $430.00 | 3 | |
Regorafenib is a small molecule multi-kinase inhibitor targeting VEGFR, PDGFR, and others. | ||||||
Vandetanib | 443913-73-3 | sc-220364 sc-220364A | 5 mg 50 mg | $167.00 $1353.00 | ||
Vandetanib is a small molecule multi-kinase inhibitor targeting VEGFR, EGFR, and RET receptors. | ||||||