Pazopanib is a potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (Flk-1), platelet-derived growth factor receptor (PDGFR) and c-kit, which are key proteins responsible for tumor growth and angiogenesis.
Soluble in water poorly (10-20 µM), DMSO (8.3 mg/ml)with slight warming, and ethanol (poorly).
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LeonLeon-Mateos et al. (PubMed ID 26386874) used the tyrosine kinase inhibitor pazopanib to inhibit VEGF, which reduced microvascular endothelial cell quantity in renal cell carcinomas. -SCBT Publication Review
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