Pazopanib CAS: 444731-52-6
MF: C21H23N7O2S
MW: 437.52
A potent and selective inhibitor of Flk-1, PDGFR and c-kit.

Pazopanib (CAS 444731-52-6)

Pazopanib | CAS 444731-52-6 is rated 5.0 out of 5 by 1.
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Alternate Names: GW-786034; 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide
Application: Pazopanib is a potent and selective inhibitor of Flk-1, PDGFR and c-kit
CAS Number: 444731-52-6
Purity: ≥98%
Molecular Weight: 437.52
Molecular Formula: C21H23N7O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Pazopanib is a potent and selective multi-targeted tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (Flk-1), platelet-derived growth factor receptor (PDGFR) and c-kit, which are key proteins responsible for tumor growth and angiogenesis.

Physical State :
Solid
Solubility :
Soluble in water poorly (10-20 µM), DMSO (8.3 mg/ml)with slight warming, and ethanol (poorly).
Storage :
Store at -20° C
Melting Point :
301-313° C
Boiling Point :
658° C (Predicted)
Density :
1.3 g/cm3 (Predicted)
Ki Data :
Vascular endothelial growth factor receptor 2: Ki= 3.16 nM (human); PDGFR-β: Ki= 3.98 nM (human); Vascular endothelial growth factor receptor 1: Ki= 15.85 nm (human); Macrophage colony stimulating factor receptor: Ki= 19.95 nM (human); Tyrosine-protein kinase receptor RET: Ki= 79.43 nM (human)
pK Values :
pKa: 10.2 (Predicted), 6.13 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10113978
SMILES :
CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N

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Certificate of Analysis

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Pazopanib (CAS 444731-52-6)  Product Citations

See how others have used Pazopanib (CAS 444731-52-6). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27822137  Kerr, LT. et al. 2016. Sarcoma. 2016: 3484673.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Leon Leon-Mateos et al. (PubMed ID 26386874) used the tyrosine kinase inhibitor pazopanib to inhibit VEGF, which reduced microvascular endothelial cell quantity in renal cell carcinomas. -SCBT Publication Review
Date published: 2015-06-21
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