RecQL1 Inhibitors

RecQL1, a key player in DNA repair processes, can be modulated by various chemical inhibitors. Ellipticine directly inhibits RecQL1 by interacting with its DNA binding sites, disrupting its ability to unwind DNA structures and contributing to increased genomic instability. Novobiocin and Ciprofloxacin indirectly influence RecQL1 by targeting DNA gyrase and inhibiting DNA topoisomerase II, respectively. These actions disrupt DNA replication and processing, impacting RecQL1's role in DNA repair and maintenance. NSC 19630 and NSC 617145 are synthetic compounds that directly inhibit RecQL1 helicase activity. Their direct inhibition affects RecQL1's function in unwinding DNA structures, leading to disruptions in DNA repair processes and potentially enhancing sensitivity to DNA-damaging agents.

6-Thioguanine and Teniposide indirectly modulate RecQL1 by incorporating into DNA and inhibiting DNA topoisomerase II, respectively. These actions alter DNA structure and processing, affecting RecQL1's interactions with DNA and contributing to disturbances in DNA repair processes. Monensin, Trifluoperazine, Acridine Orange, Berberine, and Etoposide indirectly influence RecQL1 through various mechanisms such as disrupting ion homeostasis, affecting calcium levels, intercalating with DNA, or modulating cellular metabolism. These indirect modulations impact RecQL1's function in DNA repair processes, potentially leading to disturbances in genomic stability.