RDH7 Activators
Chemical activators of RDH7 can play a crucial role in the enzyme's function by facilitating its catalytic activities. Retinol, for example, serves as a ligand that activates RDH7, allowing the enzyme to catalyze the conversion of retinol to retinal, a vital step in the visual cycle. Similarly, all-trans-retinal acts as a substrate for RDH7, enabling its enzymatic activity in the opposite direction, the reduction of retinal to retinol. The importance of cofactors such as NAD+ and NADP+ cannot be overstated, as they are integral to the oxidoreductive functions of RDH7. These cofactors bind to RDH7 and are involved in the transfer of electrons during the oxidation of retinol and the reduction of retinal. NADH and NADPH, the reduced forms of these cofactors, are also pivotal, supplying the necessary electrons for these reactions and thereby activating the enzyme.
Furthermore, RDH7's interaction with lipids such as Palmitic Acid and Phosphatidylcholine can enhance its enzymatic activity by increasing the availability of lipid substrates, which are essential for the metabolism of retinoids and steroids. These interactions facilitate the proper functioning of RDH7 within the lipid membranes where it operates. Antioxidants such as Dihydrolipoic acid and reduced Glutathione contribute to the activation of RDH7 by maintaining a reducing environment, which is favorable for the enzyme's activity. They help to preserve the redox state of RDH7, ensuring its proper function in cellular metabolism. Alpha-tocopherol, commonly known as Vitamin E, plays a protective role by defending RDH7 against oxidative stress, thus supporting the enzyme's continuous activity in processing retinal. Additionally, the presence of zinc ions, supplied by compounds like Zinc sulfate, can stabilize RDH7's structure or improve its interaction with membrane components, which may enhance the enzyme's catalytic efficiency. Collectively, these chemical activators are instrumental in maintaining and promoting the functional activity of RDH7 in its biological context.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $385.00 $2654.00 | ||
Retinol serves as a ligand for RDH7, activating the enzyme to catalyze the oxidation of retinol to retinal, a key step in the visual cycle and vitamin A metabolism. | ||||||
all-trans Retinal | 116-31-4 | sc-210778A sc-210778 | 250 mg 1 g | $129.00 $379.00 | 7 | |
All-trans-retinal acts as a substrate for RDH7, facilitating its activity in the reduction of retinal to retinol in the visual cycle. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitic Acid may enhance the lipid substrate availability for RDH7, which is involved in the metabolism of fatty acid and retinoid substrates, thereby activating RDH7's enzymatic function. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
Phosphatidylcholine constitutes membrane structures that can influence the accessibility of lipid-soluble substrates to RDH7, thus potentially activating the enzyme by increasing substrate availability. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
Glutathione in its reduced form may maintain the redox state of the cellular environment, which is critical for the activity of RDH7 as it performs oxidation and reduction reactions. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
Alpha-tocopherol can protect RDH7 from oxidative damage, thereby sustaining its activity in the reduction of retinal. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can stabilize the structure of RDH7 or influence its binding to membrane structures, thereby potentially enhancing the functional activity of the enzyme in its catalytic role. | ||||||