RDH5 Activators
RDH5 activators belong to a distinctive chemical class characterized by their ability to modulate the function of retinol dehydrogenase 5 (RDH5), a crucial enzyme involved in the retinoid metabolic pathway. Retinoids, derivatives of vitamin A, play pivotal roles in various physiological processes, including vision, cellular differentiation, and immune function. RDH5, a key player in this pathway, functions by catalyzing the conversion of retinol to retinaldehyde, a crucial step in the biosynthesis of active retinoic acid. The activation of RDH5 is critical for maintaining the delicate balance of retinoid homeostasis within cells.
Chemically, RDH5 activators typically exhibit specific structural motifs that enable them to interact selectively with the enzyme, influencing its catalytic activity. These small molecules often feature functional groups and molecular scaffolds that enhance binding affinity to RDH5, facilitating the enzyme's optimal performance in converting retinol to retinaldehyde. The modulation of RDH5 activity by these activators can have downstream effects on the entire retinoid signaling pathway, ultimately influencing cellular processes mediated by retinoids. The exploration of RDH5 activators provides valuable insights into the intricacies of retinoid metabolism and opens avenues for research aimed at understanding the broader implications of retinoid regulation in various physiological contexts.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Carotene | 7235-40-7 | sc-202485 sc-202485A sc-202485B sc-202485C | 1 g 25 g 50 g 5 kg | $80.00 $351.00 $621.00 $12791.00 | 5 | |
A precursor of vitamin A. Its conversion to retinol in the body can augment the availability of the RDH5 substrate, thereby potentially enhancing RDH5 activity. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $75.00 $120.00 | 8 | |
A form of vitamin A used in acne treatment. By modifying retinoid metabolism, it could indirectly augment the levels of RDH5 substrate, thus potentially enhancing RDH5 activity. | ||||||
Xanthophyll | 127-40-2 | sc-220391 sc-220391A | 25 mg 100 mg | $250.00 $900.00 | 2 | |
A carotenoid found in the retina. It might bolster RDH5 activity indirectly through its beneficial effects on retinal health and function. | ||||||
Zeaxanthin | 144-68-3 | sc-205544 sc-205544A | 500 µg 1 mg | $270.00 $463.00 | 5 | |
Another carotenoid found in the retina. It might bolster RDH5 activity indirectly through its beneficial effects on retinal health and function. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
An omega-3 fatty acid critical for retinal health and function. It may indirectly bolster RDH5 activity through its overall beneficial effects on the retina. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
A mineral essential for vitamin A metabolism. It could indirectly augment RDH5 activity by enhancing the availability of its substrate. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
A vitamin that can enhance the bioavailability and metabolism of vitamin A, thereby potentially increasing the availability of the RDH5 substrate. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $385.00 $2654.00 | ||
The primary substrate for 11-cis retinol dehydrogenase, the enzyme encoded by the RDH5 gene. The availability of this substrate directly stimulates RDH5 activity. | ||||||